Oxygen regulated proteins as novel therapies for
atherosclerosis, stroke and cancer - target evaluation
and drug discovery strategies.
Oxygen-regulated proteins are over-expressed by
astrocytes during experimental ischemia and also by
macrophages from atherosclerotic plaques. Since
targeted neuronal over-expression of oxygen-regulated
proteins reduces the severity of experimental models
of stroke they represent excellent CNS/cardiovascular
targets. On the other hand, oxygen-regulated proteins
are also implicated in tumor progression widening
their range of applications to cancer. A dossier has
now been produced which:
> Evaluates the proof of concept for targeting
oxygen regulated proteins for the treatment of stroke,
atherosclerosis and cancer. Strategies for ensuring
tissue specificity are also addressed.
> Analyzes the pharmaceutical development of
molecules related to oxygen regulated proteins
> Suggests screening architectures for the
development of therapeutic candidates
> Identifies academic labs that could help
expedite screening or provide biological material
(such as human tissue) to fully characterize the
clinical potential of hits
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