ActivBiotics

MISSIONActivBiotics is focused on the development and commercialization of antibacterials for the treatment of acute and chronic disease.



PRODUCT PORTFOLIO

ActivBiotics is developing rifalazil - a potent broad spectrum antibiotic that targets and inhibits the transcriptional machinery of bacteria. Previously studied in Phase I and IIA clinical trials, rifalazil is currently being planned for additional Phase II trials in several indications. In addition, ActivBiotics is owns a proprietary library of structurally related new chemical entities (NCEs).

Contact Details: 2 Oliver Street, 3rd Floor Boston MA 02109 United States of America Tel: (617) 423 9995 Fax: (617) 423 9997 Email: info@activbiotics.com WWW: www.activbiotics.com/

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Recent Publications by ActivBiotics:
Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters. PURPOSE: M40403 is a small-molecule superoxide dismutase mimetic that has...	1st August, 2008	ActivBiotics, Inc., Lexington, Massachusetts, USA.	Clin Cancer Res. 2008 Jul 1;14(13):4292-7. DOI Direct Link
Determination of rifalazil in dog plasma by liquid-liquid extraction and LC-MS/MS: quality assessment by incurred sample analysis. Incurred dog plasma samples were utilized for method quality assessment in...	4th March, 2008	ActivBiotics, Inc., 110 Hartwell Avenue, Lexington, MA 02421, USA.	J Pharm Biomed Anal. 2007 Nov 30;45(4):616-24. Epub 2007 Sep 12. DOI Direct Link
Rifalazil and other benzoxazinorifamycins in the treatment of chlamydia-based persistent infections. Rifalazil is a benzoxazinorifamycin which inhibits bacterial DNA-dependent...	6th February, 2008	ActivBiotics, Inc., Lexington, Massachusetts 02421, USA.	Arch Pharm (Weinheim). 2007 Oct;340(10):517-29. DOI Direct Link
Determination of rifalazil, a potent antibacterial agent, in human plasma by liquid-liquid extraction and LC-MS/MS. A sensitive assay for determination of rifalazil (also known as ABI-1648...	31st January, 2008	ActivBiotics, Inc., 110 Hartwell Avenue, Lexington, MA, USA.	J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Nov 1;859(1):103-10. DOI Direct Link
In vitro activity of novel rifamycins against gram-positive clinical isolates. We describe novel rifamycins that have improved activity, compared with...	4th January, 2008	ActivBiotics, Inc.,	J Antibiot (Tokyo). 2007 Sep;60(9):572-6.
→View more ActivBiotics research publications.

BioNews Results for ActivBiotics:
Spherics, Inc. Successful Bidder May Make NDA Submission	KOTA Territory News:  Aug 13 2008 5:00PM Matching: activbiotics
Spherics, Inc. Successful Bidder May Make NDA Submission	KLFY:  Aug 13 2008 4:39PM Matching: activbiotics
Spherics, Inc. Assigns Assets to Joseph F. Finn, Jr., C.P.A	KRON4:  Aug 4 2008 11:45PM Matching: activbiotics
Spherics, Inc. Assigns Assets to Joseph F. Finn, Jr., C.P.A	KOTA Territory News:  Aug 4 2008 7:02PM Matching: activbiotics
Targeting HDL in the Management of Mixed Dyslipidemia: Emerging Therapeutic Strategies for Cardiovascular Risk	Abstracts in Hematology and Oncology:  Jul 14 2008 9:22PM Matching: activbiotics
Promote your company here: BioNewsCast - Press Release Distribution	→View more ActivBiotics news.

ActivBiotics Patents:
US Patent No.	Title
7342011	Rifamycin analogs and uses thereof
7271165	Rifamycin analogs and uses thereof
7220738	Rifamycin analogs and uses thereof
7122525	Targeted therapeutics and uses thereof
7078399	Sulfhydryl rifamycins and uses thereof
→View more ActivBiotics patents.

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