Recent Publications by Active Biotech: |
Increased degradation rate of nitrososureas in media containing carbonate.
The stability of two nitrosoureas, tauromustine and lomustine, has been... | 16th October, 2008
| Department of Preclinical Development, Active Biotech Research AB, P.O.
| In Vitro Cell Dev Biol Anim. 2008 Oct 15.
DOI Direct Link |
Combining tumor-targeted superantigens with interferon-alpha results in synergistic anti-tumor effects.
In this study we explored the possibility of improving the anti-tumor... | 9th April, 2008
| Active Biotech Research AB, P.O. Box 724, SE-220 07 Lund, Sweden.
| Int Immunopharmacol. 2008 Mar;8(3):442-52. Epub 2007 Dec 7.
DOI Direct Link |
Discovery of selective small-molecule CD80 inhibitors.
Protein-protein interactions are widely found in biological systems... | 19th August, 2007
| Active Biotech Research AB, Lund, Sweden.
| J Biomol Screen. 2007 Jun;12(4):464-72. Epub 2007 Apr 13.
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Determination of the immunomodulator laquinimod in human plasma by liquid chromatography/tandem mass spectrometry; development, validation and application of two methods in clinical pharmacokinetic profiling.
Laquinimod (ABR-215062) is a synthetic compound currently undergoing... | 20th January, 2007
| Research and Development Laboratories, Active Biotech Research AB, Box
| Rapid Commun Mass Spectrom. 2006;20(22):3313-8.
DOI Direct Link |
Synthesis and reactivity of laquinimod, a quinoline-3-carboxamide: intramolecular transfer of the enol proton to a nitrogen atom as a plausible mechanism for ketene formation.
5-Chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinoline... | 12th December, 2006
| R&D Laboratories, Active Biotech Research AB, Box 724, SE-220 07 Lund,
| J Org Chem. 2006 Feb 17;71(4):1658-67.
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Inhibition of the development of chronic experimental autoimmune encephalomyelitis by laquinimod (ABR-215062) in IFN-beta k.o. and wild type mice.
Laquinimod is a novel oral immunomodulatory substance, which is currently... | 27th May, 2006
| Active Biotech AB, Box 724, SE-220 07 Lund, Sweden.
| J Neuroimmunol. 2006 Apr;173(1-2):69-78. Epub 2006 Feb 10.
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In vitro metabolism and in vivo pharmacokinetics of quinoline 3-carboxamide derivatives in various species.
The metabolism of a group of quinoline 3-carboxamide derivatives was... | 4th October, 2005
| Preclinical Development, Active Biotech Research AB, SE-220 07 Lund,
| Xenobiotica. 2005 Mar;35(3):293-304.
DOI Direct Link |
Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator.
In the present study, the involvement of cytochrome P450 enzyme(s) in the... | 30th August, 2005
| Preclinical Development, Active Biotech Research AB, Box 724, SE-220 07
| Drug Metab Dispos. 2005 Jun;33(6):866-72. Epub 2005 Mar 11.
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Influence of IGF-IR stimulation or blockade on proliferation of human renal cell carcinoma cell lines.
Several tumors secrete insulin-like growth factors (IGFs) for autocrine... | 3rd March, 2005
| Active Biotech Research AB, Department of Cellular and Molecular Biology,
| Int J Oncol. 2004 Nov;25(5):1327-36.
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Identification of protein-protein interfaces implicated in CD80-CD28 costimulatory signaling.
The B7 ligands CD80 and CD86 on APCs deliver either costimulatory or... | 7th August, 2004
| Active Biotech Research, Lund, Sweden.
| J Immunol. 2004 Jun 1;172(11):6803-9.
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The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses.
BACKGROUND: Histone deacetylase inhibitors (HDACIs) induce... | 28th May, 2004
| Department of Biology, Active Biotech Research AB, P.O. Box 724, SE-22007
| BMC Cancer. 2003 Nov 9;3:30.
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Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.
Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and... | 20th May, 2004
| Active Biotech Research AB, Box 724, SE-220 07 Lund, Sweden.
| J Med Chem. 2004 Apr 8;47(8):2075-88.
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Interplay between superantigens and immunoreceptors.
Superantigens (SAGs) cause a massive T-cell proliferation by... | 7th May, 2004
| Active Biotech Research AB, Lund, Sweden.
| Scand J Immunol. 2004 Apr;59(4):345-55.
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A fast and parallel route to cyclic isothioureas and guanidines with use of microwave-assisted chemistry.
A fast and simple approach to novel cyclic isothioureas and related... | 5th May, 2004
| Department of Drug Discovery, Active Biotech AB, Box 724, 22007 Lund,
| J Org Chem. 2004 Mar 5;69(5):1571-80.
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Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells.
The transcriptional events that control T cell tolerance are still poorly... | 5th May, 2004
| Active Biotech Research Center, Scheelevagen 22, S-223 63 Lund, Sweden.
| J Biol Chem. 2004 Feb 27;279(9):8460-8. Epub 2003 Dec 10.
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