Recent Publications by Astex Technology Limited: |
Prediction of binding modes for ligands in the cytochromes P450 and other heme-containing proteins.
The cytochromes P450 (P450s) are a family of heme-containing monooxygenase... | 13th June, 2006
| Astex Technology, Cambridge, United Kingdom.
| Proteins. 2005 Mar 1;58(4):836-44.
DOI Direct Link |
Structural biology and drug discovery.
It has long been recognized that knowledge of the 3D structures of... | 25th May, 2006
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4
| Drug Discov Today. 2005 Jul 1;10(13):895-907.
DOI Direct Link |
Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.
Since the discovery that activating mutations of the Ras GTPase were... | 25th May, 2006
| Astex Technology Ltd, 436 Cambridge Science Park, Milton Rd, Cambridge CB4
| Curr Opin Pharmacol. 2005 Aug;5(4):350-6.
DOI Direct Link |
Fragment-based lead discovery: leads by design.
Fragment-based lead discovery (also referred to as needles, shapes,... | 20th April, 2006
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4
| Drug Discov Today. 2005 Jul 15;10(14):987-92.
DOI Direct Link |
The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3).
Extensive SAR studies on the unselective BRS3 agonist,... | 8th November, 2005
| Astex
| J Pept Sci. 2005 Mar;11(3):136-41.
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The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography.
This article describes the application of a high-throughput X-ray... | 23rd June, 2005
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4
| Chembiochem. 2005 Mar;6(3):506-12.
DOI Direct Link |
Virtual screening using protein-ligand docking: avoiding artificial enrichment.
This study addresses a number of topical issues around the use of... | 22nd March, 2005
| Astex Technology Ltd., 436 Cambridge Science Park, Milton Road, Cambridge
| J Chem Inf Comput Sci. 2004 May-Jun;44(3):793-806.
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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
We describe the structure-guided optimization of the molecular fragments... | 5th March, 2005
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4
| J Med Chem. 2005 Jan 27;48(2):414-26.
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Fragment-based lead discovery using X-ray crystallography.
Fragment screening offers an alternative to traditional screening for... | 5th March, 2005
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4
| J Med Chem. 2005 Jan 27;48(2):403-13.
DOI Direct Link |
High-throughput protein crystallography and drug discovery.
Single crystal X-ray diffraction is the technique of choice for studying... | 23rd February, 2005
| Astex Technology Ltd., 436 Science Park, Milton Road, Cambridge, UK.
| Chem Soc Rev. 2004 Oct 20;33(8):558-65. Epub 2004 Sep 20.
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Apo and inhibitor complex structures of BACE (beta-secretase).
Human BACE, also known as beta-secretase, shows promise as a potential... | 16th November, 2004
| Astex Technology, 436 Cambridge Science Park, Milton Road, CB4 0QA, UK.
| J Mol Biol. 2004 Oct 15;343(2):407-16.
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Structure-guided fragment screening for lead discovery.
Fragment-based ligand screening can be a highly effective strategy for... | 29th September, 2004
| Astex Technology Ltd, 436 Cambridge Science Park, Milton Road, Cambridge,
| Curr Opin Drug Discov Devel. 2004 Jul;7(4):404-10.
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Fragment-based lead discovery.
Fragment-based ligand screening can be a highly effective strategy for... | 1st September, 2004
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4
| Nat Rev Drug Discov. 2004 Aug;3(8):660-72.
DOI Direct Link |
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.
Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds... | 11th August, 2004
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4
| Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15.
DOI Direct Link |
New lead generation strategies for protein kinase inhibitors - fragment based screening approaches.
The protein kinase superfamily represents both an enormous opportunity and... | 15th May, 2004
| Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4
| Mini Rev Med Chem. 2004 Mar;4(3):301-11.
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