Astex Technology Limited

Astex Technology is a structure-based drug discovery company pioneering the use of high throughput X-ray crystallography for the rapid identification of novel drug candidates. The company's unique structural screening approach utilizes protein crystal structures to detect the binding of drug fragments, which are then optimized into potent lead compounds. Facilitating this approach is the company's integrated drug discovery platform of HTX* technologies, which covers all aspects of structure-based research, including protein production, crystallization, structure determination, bioinformatics and computational and medicinal chemistry. Astex is focusing its drug discovery approaches on protein targets from families and/or pathways, including validated kinases, phosphatases and proteases implicated in human disease. Astex has two research agreements with Janssen Research Foundation, a division of Johnson & Johnson, and a cytochrome P450 structural biology research agreement with AstraZeneca AB.

Contact Details: 250 Cambridge Science Park, Milton Road Cambridge CBW OWE United Kingdom Tel: +44 (0) 1223 22 62 00 Fax: +44 (0) 1223 22 62 01 Email: t.haines@astex-technology.com WWW: www.Astex-Technology.com/

Recent Publications by Astex Technology Limited:
Prediction of binding modes for ligands in the cytochromes P450 and other heme-containing proteins. The cytochromes P450 (P450s) are a family of heme-containing monooxygenase...	13th June, 2006	Astex Technology, Cambridge, United Kingdom.	Proteins. 2005 Mar 1;58(4):836-44. DOI Direct Link
Structural biology and drug discovery. It has long been recognized that knowledge of the 3D structures of...	25th May, 2006	Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4	Drug Discov Today. 2005 Jul 1;10(13):895-907. DOI Direct Link
Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Since the discovery that activating mutations of the Ras GTPase were...	25th May, 2006	Astex Technology Ltd, 436 Cambridge Science Park, Milton Rd, Cambridge CB4	Curr Opin Pharmacol. 2005 Aug;5(4):350-6. DOI Direct Link
Fragment-based lead discovery: leads by design. Fragment-based lead discovery (also referred to as needles, shapes,...	20th April, 2006	Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4	Drug Discov Today. 2005 Jul 15;10(14):987-92. DOI Direct Link
The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3). Extensive SAR studies on the unselective BRS3 agonist,...	8th November, 2005	Astex	J Pept Sci. 2005 Mar;11(3):136-41. DOI Direct Link
→View more Astex Technology Limited research publications.

Astex Technology Limited Patents:
US Patent No.	Title
6546074	Protein crystal structure and method for identifying protein modulators
6484103	Crystal structure

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