Trigen is a private UK biotechnology company, based in London, developing novel drugs for the treatment of cardiovascular diseases, with a focus on thrombosis. Trigen has two products in clinical trials from its lead drug development programme; an intravenous formulation of an anti-coagulant, direct thrombin inhibitor and an oral formulation. In addition, Trigen has other programmes focused on atheroma, thrombosis and inflammation in pre-clinical development. Trigen was founded in 1992 to invest in and develop the drug discovery technologies of the world-renowned Thrombosis Research Institute ("TRI") in London.
| Contact Details: |
| Emmanuel Kaye Building, Manressa Road |
| London |
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| SW3 6LR |
| United Kingdom |
| Tel: | 0207 351 7810 |
| Fax: | 0207 661 9868 |
| Email: | trigen@trigen.co.uk |
| WWW: | www.trigen.co.uk/
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Recent Publications by Trigen: |  |
Effect of dominant negative SNAP-23 expression on platelet function.
BACKGROUND: The protein SNAP-23 is part of the secretory pathway in... | 19th December, 2008
| Trigen AG, Martinsried, Germany.
| J Thromb Haemost. 2008 Oct;6(10):1757-63. Epub 2008 Jul 28.
DOI Direct Link |
Effects of propofol on ultrasonic indicators of haemodynamic function in rabbits.
OBJECTIVE: To evaluate the cardiovascular effects of intravenous propofol... | 9th April, 2008
| Working Group of Experimental Surgery, Institute for Experimental Oncology
| Vet Anaesth Analg. 2008 Mar;35(2):100-12. Epub 2007 Sep 7.
DOI Direct Link |
Functional alterations after cardiac sodium-calcium exchanger overexpression in heart failure.
The sodium-calcium exchanger (NCX) is discussed as one of the key proteins... | 19th August, 2006
| Trigen GmbH, Fraunhoferstr. 9, D-82152 Martinsried, Germany.
| Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H488-95. Epub 2006 Apr 7.
DOI Direct Link |
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
In our continued effort to identify selective MRP1 modulators, we have... | 24th April, 2004
| Department of Medicinal Chemistry, Department of Pharmacology, Analytical
| J Med Chem. 2004 Mar 11;47(6):1339-50.
DOI Direct Link |
Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance.
Multidrug resistance mediated by P-glycoprotein (Pgp) or... | 24th April, 2004
| Department of Medicinal Chemistry, Department of Pharmacology, and
| J Med Chem. 2004 Mar 11;47(6):1329-38.
DOI Direct Link |
→View more Trigen research publications. |
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