Recent Publications by UCB Pharma: |
Retrospective population pharmacokinetic analysis of levetiracetam in children and adolescents with epilepsy: dosing recommendations.
OBJECTIVE: To characterize levetiracetam pharmacokinetics, identify... | 26th September, 2008
| Pharmacometrics, UCB Pharma SA, Braine-l'Alleud, Belgium.
| Clin Pharmacokinet. 2008;47(5):333-41.
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Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats.
Levetiracetam (Keppra((R))) is a new generation antiepileptic drug... | 30th August, 2008
| UCB PHARMA S.A., CNS Research, B-1420 Braine-l'Alleud, Belgium.
| Brain Res Bull. 2008 Aug 20.
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Effect of brivaracetam on cardiac repolarisation--a thorough QT study.
OBJECTIVES: To assess the effect on cardiac repolarisation of the... | 8th July, 2008
| Exploratory Development, UCB Pharma SA, Braine-l'Alleud, Belgium.
| Curr Med Res Opin. 2008 Aug;24(8):2327-37. Epub 2008 Jul 3.
DOI Direct Link |
SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.
SV2A, a synaptic vesicle protein, has been recently identified as a... | 13th June, 2008
| CNS Research, UCB PHARMA SA, Chemin du Foriest R9, Braine-l'Alleud,
| Neuropharmacology. 2008 Mar;54(4):715-20. Epub 2007 Dec 8.
DOI Direct Link |
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.
BACKGROUND AND PURPOSE: Screening of 12,000 compounds for binding affinity... | 27th May, 2008
| CNS Research, UCB Pharma SA, Braine-l'Alleud, Belgium.
| Br J Pharmacol. 2008 Aug;154(8):1662-71. Epub 2008 May 26.
DOI Direct Link |
Effect of levetiracetam on cardiac repolarization in healthy subjects: A single-dose, randomized, placebo- and active-controlled, four-way crossover study.
Background: Nonantiarrhythmic drugs may have the potential to prolong the... | 18th March, 2008
| Clinical Pharmacology, UCB Pharma SA, Braine-l'Alleud, Belgium.
| Clin Ther. 2008 Feb;30(2):260-70.
DOI Direct Link |
Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine.
Competition for uptake and/or efflux transporters can be responsible for... | 28th February, 2008
| Non Clinical Development Department, UCB Pharma S.A., 21 rue de Neuilly,
| Fundam Clin Pharmacol. 2008 Feb;22(1):19-23. Epub 2007 Nov 15.
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Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
OBJECTIVE: To conduct a thorough QT study of levocetirizine, a... | 15th February, 2008
| Clinical Pharmacology, UCB Pharma SA, Chemin du Foriest 1420,
| Eur J Clin Pharmacol. 2007 Nov;63(11):1011-7. Epub 2007 Sep 21.
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Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects.
This study was designed to investigate the human absorption, disposition,... | 9th February, 2008
| UCB Pharma SA,
| Drug Metab Dispos. 2008 Jan;36(1):36-45. Epub 2007 Oct 1.
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Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?
In this review, the major enzyme systems involved in vivo in the oxidative... | 4th January, 2008
| UCB Pharma, Non Clinical Development, Nanterre, France.
| Fundam Clin Pharmacol. 2007 Oct;21(5):467-80.
DOI Direct Link |
Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy.
PURPOSE: To determine whether levetiracetam (LEV) affects plasma... | 3rd January, 2008
| UCB Pharma SA, Chemin du Foriest, Braine-l'Alleud, Belgium.
| Epilepsia. 2007 Nov;48(11):2111-5. Epub 2007 Jul 25.
DOI Direct Link |
Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans.
The monooxygenases and the amine oxidases (AOs) are the major enzyme... | 6th December, 2007
| UCB Pharma, Non Clinical Development, Nanterre, France.
| J Neural Transm. 2007;114(6):787-91. Epub 2007 Mar 31.
DOI Direct Link |
Drug metabolism in the paediatric population and in the elderly.
This review focuses on one of the key factors accounting for differences... | 31st October, 2007
| UCB Pharma, 21 rue de Neuilly, 92003 Nanterre Cedex, France.
| Drug Discov Today. 2007 Aug;12(15-16):599-610. Epub 2007 Aug 2.
DOI Direct Link |
Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists.
The discovery and optimization of a novel class of potent CCR3 antagonists... | 2nd October, 2007
| UCB Pharma SA, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.
| Bioorg Med Chem Lett. 2007 Aug 1;17(15):4228-31. Epub 2007 May 17.
DOI Direct Link |
Population pharmacokinetics of levetiracetam in Japanese and Western adults.
OBJECTIVE: To assess the population pharmacokinetics of levetiracetam, a... | 27th September, 2007
| Global Pharmacometrics, UCB Pharma SA, Braine-l'Alleud, Belgium.
| Clin Pharmacokinet. 2007;46(6):503-12.
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