Recent Publications by V. Amzel & Associates: |
Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.
Phosphatidylinositide-3-kinases (PI3K) initiate a number of signaling... | 19th July, 2008
| Department of Biophysics and Biophysical Chemistry, Johns Hopkins
| Cell Cycle. 2008 May 1;7(9):1151-6. Epub 2008 Feb 27.
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Structural comparisons of class I phosphoinositide 3-kinases.
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate... | 18th July, 2008
| [1] L. Mario Amzel, Chuan-Hsiang Huang and Sandra B. Gabelli are at the
| Nat Rev Cancer. 2008 Sep;8(9):665-669. Epub 2008 Jul 17.
DOI Direct Link |
Structure, function, and mechanism of cytosolic quinone reductases.
Quinone reductases type 1 (QR1) are FAD-containing enzymes that catalyze... | 25th April, 2008
| Department of Biophysics and Biophysical Chemistry, Johns Hopkins
| Vitam Horm. 2008;78:63-84.
DOI Direct Link |
The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate.
The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that... | 29th January, 2008
| Departments of Molecular Pharmacology and Neuroscience, Albert Einstein
| Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20250-5. Epub 2007 Dec 11.
DOI Direct Link |
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
PIK3CA, one of the two most frequently mutated oncogenes in human tumors,... | 1st January, 2008
| Department of Biophysics and Biophysical Chemistry, Johns Hopkins
| Science. 2007 Dec 14;318(5857):1744-8.
DOI Direct Link |
National newspaper coverage of minority health disparities.
OBJECTIVES: To assess American newspaper coverage regarding racial and... | 19th December, 2007
| Department of General Pediatrics, Morgan Stanley Children's Hospital of
| J Natl Med Assoc. 2007 Oct;99(10):1120-5.
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Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Nudix hydrolases are a superfamily of pyrophosphatases, most of which are... | 6th December, 2007
| Department of Biophysics and Biophysical Chemistry, School of Medicine,
| Structure. 2007 Aug;15(8):1014-22.
DOI Direct Link |
Folate synthesis: an old enzyme identified.
In this issue of Structure, Amzel, Bessman, and colleagues (Gabelli et... | 6th December, 2007
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| Structure. 2007 Aug;15(8):891-2.
DOI Direct Link |
Making the right moves.
The structure of the nucleotide-free F(1)-ATPase from a thermoalkaliphilic... | 6th December, 2007
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| Structure. 2007 Aug;15(8):885-6.
DOI Direct Link |
Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in... | 2nd November, 2007
| Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical
| Nature. 2007 Sep 27;449(7161):433-7. Epub 2007 Aug 19.
DOI Direct Link |
The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation.
The molecular basis of the hydroxylation reaction of the Calpha of a... | 8th August, 2007
| Departamento de Quimica Inorganica, Analitica y Quimica-Fisica and
| J Am Chem Soc. 2006 Oct 4;128(39):12817-28.
DOI Direct Link |
Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.
Drug resistance is a major problem affecting the clinical efficacy of... | 15th June, 2007
| Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
| J Virol. 2007 May;81(10):5144-54. Epub 2007 Mar 14.
DOI Direct Link |
Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.
Serine racemase (SR) generates D-serine, a coagonist with glutamate at... | 14th April, 2007
| Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University
| Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2950-5. Epub 2007 Feb 9.
DOI Direct Link |
Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.
HOXD13, the homeobox-containing gene located at the most 5' end of the... | 14th March, 2007
| Department of Medical Genetics and National Key Laboratory of Medical
| Am J Hum Genet. 2007 Feb;80(2):361-71. Epub 2007 Jan 3.
DOI Direct Link |
Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair... | 21st December, 2006
| Department of Pharmacology and Molecular Sciences, 725 North Wolfe Street,
| Nucleic Acids Res. 2006;34(20):5872-9. Epub 2006 Oct 24.
DOI Direct Link |
