Xenome Limited

Xenome aims to develop new treatments for pain, particularly intractable pain as experienced by many cancer patients, as well as other neurological conditions for which there is an unmet clinical need, e.g stroke.Xenome has an exclusive license to a collection of molecules and related technologies discovered by the Centre for Drug Design and Development (the Centre) at the University of Queensland (now part of the Institute for Molecular Bioscience). These molecules, know as conotoxins, were isolated from the venom of several species of cone shells collected from the Great Barrier Reef and have been shown to selectively inhibit proteins known as ion-channels. Inhibition of certain ion-channels is known to control various types of pain.

Xenome intends to test naturally occurring contoxins, as well as novel molecules, made chemically in the laboratory, for their pharmacological activity. Potentially useful molecules will then be tested in animal models for pain and other neurological conditions.

Contact Details: Australia Tel: Fax: Email: WWW: www.medica.com.au/

Recent Publications by Xenome Limited:
chi-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain ( perpendicular). Norepinephrine (NE) amplifies the strength of descending pain inhibition,...	29th October, 2009	Xenome Ltd., 120 Meiers Road, Indooroopilly, Queensland, Australia 4068.	J Med Chem. 2009 Oct 27. DOI Direct Link
High-throughput synthesis of conopeptides: a safety-catch linker approach enabling disulfide formation in 96-well format. Conotoxins exhibit a high degree of selectivity and potency for a range of...	27th September, 2007	Xenome Ltd, 120 Meiers Road, Indooroopilly 4068, Australia.	J Pept Sci. 2007 Feb;13(2):133-41. DOI Direct Link
Taxonomy of Australian Funnel-web spiders using rp-HPLC/ESI-MS profiling techniques. The complex nature of venom from spider species offers a unique natural...	30th June, 2006	Xenome Ltd, P.O. Box 6295, St Lucia, Qld 4067, Australia.	Toxicon. 2006 May;47(6):614-27. Epub 2006 Mar 22. DOI Direct Link
Australian funnel-web spider venom analyzed with on-line RP-HPLC techniques. The complex nature of venom from spider species offers a unique natural...	25th March, 2004	Xenome Ltd., Indooroopilly, Queensland, Australia.	Methods Mol Biol. 2004;251:307-22.

Xenome Limited Patents:
US Patent No.	Title
7507717	Type II chi-conotoxin peptides (noradrenaline transporter inhibitors)
7368432	Conotoxin peptides
7326682	Conotoxin peptides

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