Adherex Technologies Incorporated

Adherex Technologies is a biotechnology company developing novel therapeutics based on cell adhesion technologies. Adherex is currently developing a portfolio of biologically active small molecules based on the cadherin family of cell adhesion molecules. Cadherins are the major biological glues that hold tissues intact. They play an important role in maintaining the integrity of tissues and barriers in the body, development, recovery from injury, and cancer. Adherex has successfully developed compounds that alter the level of adhesion between cells. The Company is now investigating the applications of these cell adhesion modulators.

Adherex has discovered a revolutionary new approach to cancer therapy. Our cadherin modulating drug Exherin has displayed potent anti-vascular activity. At therapeutic concentrations it effectively destroys tumor vessels without harming normal vessels. Though initial examination of Exherin's effects may suggest that they are like those of other anti-angiogenesis agents (which block the process of blood vessel formation), Exherin goes far beyond anything those agents can do. Exherin not only stops growth of new tumor vessels, it destroys existing tumor vessels. Adherex is the first and only company in the world that is focused on the relationship between cell-cell adhesion and cancer.

Contact Details: 600 Peter Morand CrescentSuite 340 Ottawa Ontario K1G 5Z3 Canada Tel: (613) 738-8000 Fax: (613) 738-9060 Email: info@adherex.com WWW: www.adherex.com/

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Recent Publications by Adherex Technologies Incorporated:
Development and validation of a high-performance liquid chromatographic method for the analysis of budesonide. A simple, rapid, and stability indicating reversed-phase high-performance...	14th March, 2007	Adherex Technologies Inc., Durham, NC 27713, USA.	J Pharm Biomed Anal. 2006 Feb 13;40(2):423-8. Epub 2005 Sep 6. DOI Direct Link

BioNews Results for Adherex Technologies Incorporated:
Ionian Technologies, Inc. Signs Molecular Diagnostic Manufacturing Agreement With Roche Diagnostics	Genetic Engineering News:  Nov 14 2009 12:48AM Matching: technologies
TRADE NEWS: Agilent Technologies Expands Ultra-High-Performance Liquid Chromatography Portfolio With New High-	Pharma Live:  Nov 14 2009 12:33AM Matching: technologies
Del Global Technologies Announces an Agreement in Principle to Sell Its Del Medical Imaging Business	Freshnews.com:  Nov 13 2009 2:10AM Matching: technologies
Roche and Ionian Technologies Strike Product-Development Pact	GenomeWeb:  Nov 13 2009 9:55PM Matching: technologies
Del Global Technologies Announces an Agreement in Principle to Sell Its Del Medical Imaging Business	Genetic Engineering News:  Nov 13 2009 7:28AM Matching: technologies
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Adherex Technologies Incorporated Clinical Trials:
A Study of ADH-1 in Combination With Normothermic Isolated Limb Infusion of Melphalan

Adherex Technologies Incorporated Patents:
US Patent No.	Title
7481999	Compounds and methods for modulating OB-cadherin-mediated function
6638911	Compounds and methods for modulating desmosomal cadherin-mediated functions
6593297	Compounds and methods for inhibiting cancer metastasis
6569996	Antibody that specifically binds to the cadherin-5 cell adhesion recognition sequence
6472368	Compounds and methods for modulating adhesion molecule function
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