BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical industry. Designed to accelerate clients’ discovery programmes, BioFocus’ products and services are offered on a flexible basis and include diverse or targeted (SoftFocusTM) screening libraries, assay development, high-throughput screening, hit-to-lead optimisation and all associated informatics. Clients have access to propriety technologies such as Predictive Array DesignTM
(a patented library design methodology) and a range of proprietary screening platforms. The company has specialized expertise in Kinase, GPCR and ion-channel targets and offers or is developing opportunities for drug discovery partnerships in these areas. Current partners include Aventis Cropscience, Biovitrum, GlaxoSmithKline, Millennium, Oxford GlycoSciences, Pfizer, Roche and Teijin.
| Contact Details: |
| Chesterford Research Park |
| Saffron Walden |
| Essex |
| CB10 1XL |
| United Kingdom |
| Tel: | +44 1799 533 500 |
| Fax: | +44 1799 531 495 |
| Email: | |
| WWW: | www.biofocus.co.uk/
|
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Recent Publications by BioFocus: |  |
Protein structure prediction.
Protein structure prediction has matured over the past few years to the... | 21st August, 2008
| Biofocus DPI, London, United Kingdom.
| Methods Mol Biol. 2008;453:33-85.
DOI Direct Link |
Automatic QSAR modeling of ADME properties: blood-brain barrier penetration and aqueous solubility.
In this article, we present an automatic model generation process for... | 6th August, 2008
| BioFocus DPI Ltd., Darwin Building, Chesterford Research Park, Saffron
| J Comput Aided Mol Des. 2008 Jun-Jul;22(6-7):431-40. Epub 2008 Feb 14.
DOI Direct Link |
How large does a compound screening collection need to be?
Increasingly, chemical libraries are being produced which are focused on a... | 5th August, 2008
| BioFocus DPI, Chesterford Research Park, Saffron Walden, Essex, UK.
| Comb Chem High Throughput Screen. 2008 Jul;11(6):482-93.
|
Bone disease drug discovery: examining the interactions between osteoblast and osteoclast.
BACKGROUND: Existing drugs, including bisphosphonates and calcitonin,... | 14th March, 2008
| BioFocus DPI, A Galapagos Company, Division of Medicinal Chemistry, 9640
| Expert Opin Ther Targets. 2008 Feb;12(2):239-51.
DOI Direct Link |
Use of FLIPR membrane potential dyes for validation of high-throughput screening with the FLIPR and microARCS technologies: identification of ion channel modulators acting on the GABA(A) receptor.
Fluorometric imaging plate reader (FLIPR) membrane potential dyes... | 14th February, 2008
| Biofocus DPI AG, Allschwil, Switzerland.
| J Biomol Screen. 2008 Mar;13(3):218-28. Epub 2008 Feb 12.
DOI Direct Link |
→View more BioFocus research publications. |
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