Advanced Centre for Biochemical Engineering

The Advanced Centre has been a Research Council Centre since 1987, a national Interdisciplinary Research Centre since 1991 and is now operated as a Biotechnology and Biological Sciences Research Council (BBSRC) sponsored institute. In the last decade the Centre has received the largest research grant support in the field from the UK research councils. The Advanced Centre focuses on research which draws together a coherent view of whole bioprocesses. By collaborating with leading scientists in over 20 universities it is able to work on many of the most exciting frontiers: such as the production of plasmid genes for therapy and of antibody fragments for targeting, the process implications of metabolic engineering and biotransformation engineering for chiral chemicals. The Centre is also exploring the challenges of producing chemicals and pharmaceuticals from transgenic plants.



The Centre’s whole-process oriented research links its fermentation, downstream processing and biotransformation studies and they are further integrated by research on monitoring, modelling and scale-down of complete bioprocesses. The value of this work is enhanced by the ability in the Centre to verify the scale-down and modelling at large-pilot scale. In the 1990s, £20M has been invested in outstanding new facilities. The Centre is part of one of the top four multifaculty research universities in the UK.

Contact Details: University College LondonGower Street London Greater London WC1E 6BT United Kingdom Tel: 020 7387 7050 Fax: 020 7380 7920 Email: WWW: www.afengineering.co.uk/

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Recent Publications by Advanced Centre for Biochemical Engineering:
Assessing the value of autologous and allogeneic cells for regenerative medicine. The advantages and disadvantages of autologous and allogeneic human cells...	12th November, 2009	Advanced Centre for Biochemical Engineering, University College London,	Regen Med. 2009 Nov;4(6):835-53. DOI Direct Link
Regen: the industry responsible for cell-based therapies. The advantages and disadvantages of autologous and allogeneic human cells...	12th November, 2009	Advanced Centre for Biochemical Engineering, University College London,	Regen Med. 2009 Nov;4(6):783-5. DOI Direct Link
Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles. This article demonstrates how the intracellular compartmentalization of...	27th October, 2009	Dept. of Biochemical Engineering, Advanced Centre for Biochemical	Biotechnol Prog. 2009 Oct 23. DOI Direct Link
Ultra scale-down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths. This article describes how a combination of an ultra scale-down (USD)...	16th October, 2009	Advanced Centre for Biochemical Engineering, Department of Biochemical	Biotechnol Bioeng. 2009 Oct 1;104(2):321-31. DOI Direct Link
A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies. A microscale approach is described which screens conditions for recovering...	10th October, 2009	The Advanced Centre for Biochemical Engineering, University College	J Chromatogr A. 2009 Nov 6;1216(45):7806-15. Epub 2009 Sep 20. DOI Direct Link
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