The Advanced Centre has been a Research Council Centre since 1987, a national Interdisciplinary Research Centre since 1991 and is now operated as a Biotechnology and Biological Sciences Research Council (BBSRC) sponsored institute. In the last decade the Centre has received the largest research grant support in the field from the UK research councils. The Advanced Centre focuses on research which draws together a coherent view of whole bioprocesses. By collaborating with leading scientists in over 20 universities it is able to work on many of the most exciting frontiers: such as the production of plasmid genes for therapy and of antibody fragments for targeting, the process implications of metabolic engineering and biotransformation engineering for chiral chemicals. The Centre is also exploring the challenges of producing chemicals and pharmaceuticals from transgenic plants.
The Centre’s whole-process oriented research links its fermentation, downstream processing and biotransformation studies and they are further integrated by research on monitoring, modelling and scale-down of complete bioprocesses. The value of this work is enhanced by the ability in the Centre to verify the scale-down and modelling at large-pilot scale. In the 1990s, £20M has been invested in outstanding new facilities. The Centre is part of one of the top four multifaculty research universities in the UK.
| Contact Details: |
| University College LondonGower Street |
| London |
| Greater London |
| WC1E 6BT |
| United Kingdom |
| Tel: | 020 7387 7050 |
| Fax: | 020 7380 7920 |
| Email: | |
| WWW: | www.afengineering.co.uk/
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Recent Publications by Advanced Centre for Biochemical Engineering: |  |
Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde.
Mutants of transketolase (TK) with improved substrate specificity towards... | 13th August, 2008
| Advanced Centre for Biochemical Engineering, Department of Biochemical
| J Biotechnol. 2008 Apr 30;134(3-4):240-5. Epub 2008 Feb 13.
DOI Direct Link |
The strong financial case for regenerative medicine and the regen industry.
Although the therapeutic promise of regenerative medicine is immensely... | 8th August, 2008
| Advanced Centre for Biochemical Engineering, University College London,
| Regen Med. 2008 May;3(3):351-63.
DOI Direct Link |
Quantification of power consumption and oxygen transfer characteristics of a stirred miniature bioreactor for predictive fermentation scale-up.
Miniature parallel bioreactors are becoming increasingly important as... | 8th August, 2008
| Department of Biochemical Engineering, The Advanced Centre for Biochemical
| Biotechnol Bioeng. 2008 Aug 15;100(6):1144-55.
DOI Direct Link |
Impact of clarification strategy on chromatographic separations: Pre-processing of cell homogenates.
This research focused on how the extent and type of primary solid-liquid... | 5th August, 2008
| The Advanced Centre for Biochemical Engineering, Department for
| Biotechnol Bioeng. 2008 Aug 1;100(5):941-9.
DOI Direct Link |
Boron based separations for in situ recovery of L-erythrulose from transketolase-catalyzed condensation.
In this article we report on the application of in situ product removal... | 19th July, 2008
| The Advanced Centre for Biochemical Engineering, Department of Chemical &
| Biotechnol Bioeng. 1997 Nov 5;56(3):345-51.
DOI Direct Link |
→View more Advanced Centre for Biochemical Engineering research publications. |
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