Recent Publications by Abbott Laboratories: |
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo.
ABT-263 is a potent, orally bioavailable inhibitor of the antiapoptotic... | 13th November, 2008
| Global Pharmaceutical Research and Development, Abbott Laboratories,
| Mol Cancer Ther. 2008 Oct;7(10):3265-74.
DOI Direct Link |
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.
Hepatotoxicity is a common cause of failure in drug discovery and... | 11th November, 2008
| Department of Cellular, Molecular and Exploratory Toxicology, Global
| Toxicol Lett. 2008 Oct 17.
DOI Direct Link |
Behavioral profile of P2X(7) receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders.
The purinergic P2X(7) receptor is a ligand-gated ion channel found on... | 11th November, 2008
| Neuroscience Research, Global Pharmaceutical Research and Development,
| Behav Brain Res. 2008 Oct 18.
DOI Direct Link |
Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin.
Griseofulvin is a small rigid molecule that shows relatively high... | 7th November, 2008
| Global Pharmaceutical R&D, and Global Pharmaceutical Operations, Abbott
| Mol Pharm. 2008 Nov 6.
DOI Direct Link |
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.
Poly(ADP-ribose) polymerase (PARP) senses DNA breaks and facilitates DNA... | 6th November, 2008
| Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL, USA.
| Mol Cancer Res. 2008 Oct;6(10):1621-9.
DOI Direct Link |
Randomized, Phase II Study of the Thrombospondin-1-Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Soft Tissue Sarcoma.
PURPOSE: Sarcomas are among the most proangiogenic malignancies in... | 5th November, 2008
| University of Michigan Medical School, Ann Arbor, MI; Cancer Therapy and
| J Clin Oncol. 2008 Nov 3.
DOI Direct Link |
Cloning and characterization of the monkey histamine H(3) receptor isoforms.
We have recently identified five splice isoforms of the histamine H(3)... | 4th November, 2008
| Neuroscience Research, Global Pharmaceutical Research Division, Abbott
| Eur J Pharmacol. 2008 Oct 21.
DOI Direct Link |
In search of negative allosteric modulators of biological targets.
The value of using negative allosteric modulators of protein function in... | 1st November, 2008
| Abbott Laboratories, R4PN/J35, 200 Abbott Park Road, Abbott Park, IL
| Drug Discov Today. 2008 Oct 27.
DOI Direct Link |
Psoriasis Area and Severity Index: Nuts and bolts of measuring disease severity in psoriasis.
The value of using negative allosteric modulators of protein function in... | 23rd October, 2008
| Immunology Development, Abbott Laboratories, Abbott Park, IL 60064-6149,
| Clin Dermatol. 2008 Nov-Dec;26(6):653-6.
DOI Direct Link |
Characterization of a Cannabinoid CB2 Receptor Selective Agonist, A-836339, in In Vitro Pharmacological assays and In Vivo Pain Models.
Studies demonstrating the anti-hyperalgesic and anti-allodynic effects of... | 22nd October, 2008
| Abbott Laboratories.
| J Pharmacol Exp Ther. 2008 Oct 17.
DOI Direct Link |
Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt.
In previously reported applications of salting-out assisted liquid/liquid... | 18th October, 2008
| Department of Drug Analysis, Abbott Laboratories, 100 Abbott Park Road,
| J Pharm Biomed Anal. 2008 Sep 9.
DOI Direct Link |
Success is not necessarily automatic.
There are a number of factors (planning, process optimization,... | 18th October, 2008
| Pharmaceutical and Analytical Research and Development Abbott Laboratories
| J Automat Chem. 1998;20(4):109-10.
DOI Direct Link |
A fully automated liquid-liquid extraction system utilizing interface detection.
The development of the Abbott Liquid-Liquid Extraction Station was a... | 18th October, 2008
| Abbott Laboratories Abbott Park IL USA.
| J Autom Methods Manag Chem. 2000;22(6):187-94.
DOI Direct Link |
Comparison of cardiovascular effects in conscious and pentobarbital anesthetized dogs.
ABT-263 is a potent, orally bioavailable inhibitor of the antiapoptotic... | 14th October, 2008
| Abbott Laboratories, Abbott Park, IL, 60064, USA.
| J Pharmacol Toxicol Methods. 2008 September - October;58(2):148.
DOI Direct Link |
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Overexpression of prosurvival proteins such as Bcl-2 and Bcl-X L has been... | 10th October, 2008
| Cancer Research, Global Pharmaceutical Research and Development, Abbott
| J Med Chem. 2008 Nov 13;51(21):6902-15. Epub 2008 Oct 8.
DOI Direct Link |
