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Applied Molecular Evolution

Applied Molecular Evolution (AME) is a leader in applying directed molecular evolution to improve healthcare by discovering, optimizing and developing human biotherapeutics. Since its inception, AME’s principal focus has been on applying its proprietary AMEsystem™ technology platform to the full range of protein therapeutic candidates including antibodies, cytokines, hormones and enzymes to develop novel human biotherapeutic candidates.
Since February 2004, AME has been a wholly-owned subsidiary of Eli Lilly and Company and is an integral part of Lilly’s research organization. Lilly, a leading innovation-driven corporation is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Lilly provides answers – through medicines and information – for some of the world’s most urgent medical needs.

While geographically separate, AME works closely with Lilly colleagues in Indianapolis and around the world, sharing a corporate legacy of integrity and commitment to quality that spans more than a century.


Contact Details:
3520 Dunhill street
San Diego
California
92121
United States of America
Tel:858.597.4990
Fax:858.597.4950
Email:
WWW:

www.ame.biz/




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Recent Publications by Applied Molecular Evolution:

Cross-strand pairing and amyloid assembly.
Amino acid cross-strand pairing interactions along a beta-sheet surface...
4th October, 2008
Center for Fundamental and Applied Molecular Evolution, Department of Biochemistry. 2008 Sep 23;47(38):10018-26. Epub 2008 Aug 30.
DOI Direct Link
Capturing the VirA/VirG TCS of Agrobacterium tumefaciens.
Two-component systems (TCS) regulate pathogenic commitment in many...
17th September, 2008
Center for Fundamental and Applied Molecular Evolution, Department of Adv Exp Med Biol. 2008;631:161-77.
Synthesis of novel bicyclic nucleosides with 3,6-anhydro sugar moiety.
Based on the biological importance of conformationally restricted...
13th September, 2008
Foundation for Applied Molecular Evolution, Gainesville, Florida 32601, Nucleosides Nucleotides Nucleic Acids. 2008 Oct;27(10):1097-106.
DOI Direct Link
Synthetic biology for improved personalized medicine.
Tools to re-sequence the genomes of individual patients having well...
9th September, 2008
Foundation for Applied Molecular Evolution, 1115 NW 4 Street, Gainesville, Nucleic Acids Symp Ser (Oxf). 2008;(52):243-4.
DOI Direct Link
Self-Avoiding Molecular Recognition Systems (SAMRS).
Reported here is a "Self-Avoiding Molecular Recognition Systems" (SAMRS),...
9th September, 2008
Foundation for Applied Molecular Evolution, 1115 NW 4 Street, Gainesville, Nucleic Acids Symp Ser (Oxf). 2008;(52):129-30.
DOI Direct Link

View more Applied Molecular Evolution research publications.

BioNews Results for Applied Molecular Evolution:

Large New Lab for Pharmaceutical Giant
Voice of San Diego:  Sep 30 2008 3:32AM Matching: applied molecular evolution
Lilly Signs 10-Year Lease on UTC Lab Facility
San Diego Business Journal:  Sep 26 2008 5:00PM Matching: applied molecular evolution
BIOTECH: Biotech development surge continues
North County Times:  Sep 25 2008 9:58AM Matching: applied molecular evolution

Applied Molecular Evolution Patents:

US Patent No.Title
7422745 Methods of treating cancer with .sub.v.alpha..beta..sub.3-specific antibodies
6787638 Tumor specific human monoclonal antibodies and methods of use
6893845 Surface expression libraries of heteromeric receptors
7049121 Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
7070973 Butyrylcholinesterase variants and methods of use

View more Applied Molecular Evolution patents.

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