Beta-Cell

Beta-Cell is engaged in the development and commercialisation of innovative cell and drug therapies for the treatment of diabetes. The primary therapeutic focus of the company is on beta-cells, the highly specialized endocrine cells located in pancreatic islets and responsible for producing insulin. Beta-Cell has an advanced pre-clinical xeno-transplantation program based on its proprietary technologies to isolate and transplant fetal pig pancreatic endocrine (FPPE) cells. As demonstrated by the company, transplanted FPPE cells have the ability to restore normoglycemia in immune competent diabetic mice. Follow-up experiments with FPPE cells in large animal models are in progress. Concurrently, Beta-Cell is conducting research projects aimed at stimulating the proliferation, survival and differentiation of precursor / stem cells into functional beta-cells. In addition to its core programs in beta-cell therapy, the company has adopted a dynamic business strategy to maximize the commercial potential of its different technology platforms. The first product made available in this process is the access to high-quality FPPE cells produced in large amounts under GLP conditions. The company also provides a combination of services using in vitro test systems based on pancreatic islets and endocrine / exocrine cells from rat, pig and human sources to accelerate the identification and validation of novel diabetes drug candidates. The third product currently commercialised by Beta-Cell is a robust murine in vivo model to evaluate drug candidates for the induction of immune suppression or immune tolerance upon xeno-transplantation. Finally, Beta-Cell is active in the development of innovative multiplex detection tools for porcine pathogens.

Contact Details: Researchpark Z1 310 Zellik 1731 Belgium Tel: Fax: Email: WWW: www.beta-cell.com/

Recent Publications by Beta-Cell:
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. OBJECTIVE: Rapamycin is an immunosuppressive drug currently used to...	2nd October, 2008	Telethon-Juvenile Diabetes Research Foundation Center for Beta Cell	Diabetes. 2008 Sep;57(9):2341-7. Epub 2008 Jun 16. DOI Direct Link
Cell-based treatments for diabetes. In Type 1 diabetes mellitus the insulin-secreting beta-cells in pancreatic...	26th July, 2008	Beta Cell Group, Division of Reproduction and Endocrinology, King's	Drug Discov Today. 2008 Oct;13(19-20):888-93. Epub 2008 Aug 4. DOI Direct Link
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. Successful transplantation requires the prevention of allograft rejection...	2nd July, 2008	Immunology of Diabetes Unit and Clinical Transplant Unit,	J Clin Invest. 2008 May;118(5):1806-14. DOI Direct Link
Insulin signalling in islets. Studies in transgenic animals, rodent insulin-secreting cell lines and...	17th May, 2008	Beta Cell Development & Function Group, King's College London, London, UK.	Biochem Soc Trans. 2008 Jun;36(Pt 3):290-3. DOI Direct Link
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Sustained activation of AMP-activated protein kinase (AMPK) induces...	17th May, 2008	Diabetes Research Center, Brussels Free University, VUB, Partner of the	Biochem Pharmacol. 2008 May 15;75(10):1981-93. Epub 2008 Feb 26. DOI Direct Link
→View more Beta-Cell research publications.

BioNews Results for Beta-Cell:
New Class of Drugs Might Cause Congenital Heart Defects	HealthCentral.com:  Oct 5 2008 7:34AM Matching: beta cell
New Class of Drugs Might Cause Congenital Heart Defects	Yahoo! News:  Oct 5 2008 3:59AM Matching: beta cell
Identification of ligands by selective amplification of cells transfected with a 5HT2A receptor	PharmCast:  Oct 4 2008 1:21AM Matching: beta cell
Treatment of autoimmune conditions with Copolymer 1 and related Copolymers	PharmCast:  Oct 4 2008 1:21AM Matching: beta cell
ImClone Mystery Bidder Revealed	Cafepharma:  Oct 4 2008 4:54AM Matching: beta cell
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