Beta-Cell

Beta-Cell is engaged in the development and commercialisation of innovative cell and drug therapies for the treatment of diabetes. The primary therapeutic focus of the company is on beta-cells, the highly specialized endocrine cells located in pancreatic islets and responsible for producing insulin. Beta-Cell has an advanced pre-clinical xeno-transplantation program based on its proprietary technologies to isolate and transplant fetal pig pancreatic endocrine (FPPE) cells. As demonstrated by the company, transplanted FPPE cells have the ability to restore normoglycemia in immune competent diabetic mice. Follow-up experiments with FPPE cells in large animal models are in progress. Concurrently, Beta-Cell is conducting research projects aimed at stimulating the proliferation, survival and differentiation of precursor / stem cells into functional beta-cells. In addition to its core programs in beta-cell therapy, the company has adopted a dynamic business strategy to maximize the commercial potential of its different technology platforms. The first product made available in this process is the access to high-quality FPPE cells produced in large amounts under GLP conditions. The company also provides a combination of services using in vitro test systems based on pancreatic islets and endocrine / exocrine cells from rat, pig and human sources to accelerate the identification and validation of novel diabetes drug candidates. The third product currently commercialised by Beta-Cell is a robust murine in vivo model to evaluate drug candidates for the induction of immune suppression or immune tolerance upon xeno-transplantation. Finally, Beta-Cell is active in the development of innovative multiplex detection tools for porcine pathogens.

Contact Details: Researchpark Z1 310 Zellik 1731 Belgium Tel: Fax: Email: WWW: www.beta-cell.com/

Recent Publications by Beta-Cell:
Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY). Objective: To evaluate the heterogeneity in the clinical expression in a...	12th November, 2009	IMABIS Foundation and Center for the Study of Pancreatic Beta-cell	Diabetes Care. 2009 Nov 10. DOI Direct Link
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. Chronically elevated levels of fatty acids-FA can cause beta cell death in...	30th September, 2009	Diabetes Research Center, Brussels Free University-VUB, and JDRF Center	PLoS One. 2009 Sep 29;4(9):e7266. DOI Direct Link
Mesenchymal stem cell homing capacity. Mesenchymal stem cells (MSCs) are the stromal component of bone marrow...	9th July, 2009	Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele	Transplantation. 2009 May 15;87(9 Suppl):S42-5. DOI Direct Link
Prevention of atherosclerosis in patients living with HIV. INVESTIGATIONAL PRODUCT: Rosuvastatin (Crestor; Astra Zeneca). ACTIVE...	20th June, 2009	General Medicine and Prevention of Vascular Disorders, Beta Cell Diabetes	Vasc Health Risk Manag. 2009;5(1):287-300. Epub 2009 Apr 8.
Characterisation of the insulinotropic activity of an aqueous extract of Gymnema sylvestre in mouse beta-cells and human islets of Langerhans. Leaves of the Gymnema sylvestre (GS) plant have been used to treat...	17th June, 2009	Beta Cell Development & Function Group and Division of Gene & Cell Based	Cell Physiol Biochem. 2009;23(1-3):125-32. Epub 2009 Feb 18. DOI Direct Link
→View more Beta-Cell research publications.

BioNews Results for Beta-Cell:
Mouse gene suppresses Alzheimer's plaques and tangles	Innovations Report:  Nov 16 2009 4:41AM Matching: beta cell
Mechanism of Insulin Production That can Lead to Better Treatment for Diabetes Discovered	MedIndia:  Nov 15 2009 5:47PM Matching: beta cell
USC researcher and expert in metabolism to receive Columbia's 2009 Naomi Berrie Award	Genetic Engineering News:  Nov 15 2009 11:58AM Matching: beta cell
Functional Genetics Announces Discovery of Target That Regulates Alzheimer's Disease	PR-USA.net:  Nov 15 2009 12:47PM Matching: beta cell
Pioneering Discoveries About The Development Of Cells	Medical News Today:  Nov 14 2009 10:14AM Matching: beta cell
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