Biotica Technology Limited

Biotica Technology Limited is a privately held biotechnology company focused on the discovery of novel biopharmaceuticals through the targeted alteration of biosynthetic pathways producing natural products. Its proprietary platform technologies enable both the specific and combinatorial biosynthesis of bioactive polyketides, a particularly diverse class of natural products that have proven to be a rich source of commercially significant pharmaceuticals and agricultural chemicals. Biotica is applying its technologies to the discovery of novel polyketide-derived pharmaceuticals within its therapeutic focus on cancer and other proliferative diseases. Biotica has identified lead molecules addressing specific targets within its chosen focus areas and is applying its technologies in exploratory research to optimise those leads.

Contact Details: 181A Huntingdon Road Cambridge Cambridgeshire CB3 ODJ United Kingdom Tel: +44 (0) 1223 276 904 Fax: +44 (0) 1223 276 904 Email: info@biotica.co.uk WWW: www.biotica.co.uk/

Recent Publications by Biotica Technology Limited:
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. The glycosylation of natural product scaffolds with highly modified...	20th September, 2008	Biotica Technology Ltd, Chesterford Research Park, Little Chesterford,	Org Biomol Chem. 2008 Sep 21;6(18):3315-27. Epub 2008 Jul 28. DOI Direct Link
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. A biosynthetic medicinal chemistry approach was applied to the...	20th September, 2008	Biotica Technology Limited, Chesterford Research Park, Nr. Saffron Walden,	J Med Chem. 2008 Sep 25;51(18):5494-7. DOI Direct Link
Molecular characterization of macbecin as an Hsp90 inhibitor. Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being...	10th July, 2008	Biotica Technology Limited, Chesterford Research Park, Essex CB10 1XL,	J Med Chem. 2008 May 8;51(9):2853-7. Epub 2008 Mar 22. DOI Direct Link
Drug discovery beyond the 'rule-of-five'. Although a very useful guideline for orally bioavailable small-molecule...	15th May, 2008	Biotica Technology Ltd., Chesterford Research Park, Little Chesterford nr	Curr Opin Biotechnol. 2007 Dec;18(6):478-88. Epub 2007 Nov 26. DOI Direct Link
Engineering of the spinosyn PKS: directing starter unit incorporation. The spinosyns are a family of potent and highly selective insect control...	1st February, 2007	Biotica Technology Limited, Chesterford Research Park, Essex, CB10 1XL,	J Nat Prod. 2006 Dec;69(12):1702-10. DOI Direct Link
→View more Biotica Technology Limited research publications.

BioNews Results for Biotica Technology Limited:
New Drug Delivery for Self-Administration Report now Available	Pharma Live:  Oct 5 2008 10:36PM Matching: technology
Ablynx Is Awarded ,1.8 Million Grant To Explorenovel Methods For Uses Of Nanobodies	Pharma Live:  Oct 6 2008 12:47AM Matching: technology
GM corn testing for the ACT	Stock Journal:  Oct 6 2008 12:44AM Matching: technology
Luminex Corporation Hosts Sixth Annual Planet xMap Europe 2008 Symposium	Pharma Live:  Oct 5 2008 7:50AM Matching: technology
Examine Current and Possible Opportunities within the Transdermal Skin Patches Markets	Pharma Live:  Oct 5 2008 10:35PM Matching: technology
Promote your company here: BioNewsCast - Press Release Distribution	→View more Biotica Technology Limited news.

Biotica Technology Limited Patents:
US Patent No.	Title
7390895	Production of polyketides and other natural products
6437151	Erythromycins and process for their preparation
6960453	Hybrid polyketide synthases combining heterologous loading and extender modules
7001747	Nucleic acid molecules encoding modified polyketide synthases containing polylinkers and uses thereof
7018808	Polyketides and their synthesis and use
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