BioStratum Incorporated

BioStratum is focused on the discovery, development and commercialization of novel therapeutic agents for the treatment of diabetes and diabetic complications. BioStratum's pipeline is led by Pyridorin™ a small molecule drug for the treatment of diabetic kidney disease, followed by pre-clinical compounds that will treat other diabetic complications and cancer. Pyridorin has been granted Fast Track status by the FDA and has been shown to be safe and potentially effective in treating diabetic patients with kidney disease. In our recently completed Phase II studies, Pyridorin decreased in a statistically significant manner the rate of rise in serum creatinine, a leading indicator of diabetic kidney disease progression. We believe these results validate BioStratum's approach to treating diabetic complications by inhibiting the formation of harmful advanced glycation endproducts or "AGEs", and support the aggressive ongoing campaign to identify and develop second-generation AGE inhibitors

Contact Details: 2300 Englert Drive; Suite G North Carolina 27713 United States of America Tel: 919-433-1000 Fax: 919-433-1010 Email: info@biostratum.com WWW: www.biostratum.com/

Recent Publications by BioStratum Incorporated:
Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design. Aminoguanidine and pyridoxamine (Pyridorintrade mark), two major...	28th October, 2005	BioStratum Incorporated, 4620 Creekstone Dr., Durham, NC 27703, USA.	Ann N Y Acad Sci. 2005 Jun;1043:793-806. DOI Direct Link
Reflections on Edsall's carbonic anhydrase: paradoxes of an ultra fast enzyme. John Edsall's investigations of human erythrocyte carbonic anhydrase, a...	5th December, 2003	BioStratum Incorporated, 4620 Creekstone Drive, Suite 200, Durham, North	Biophys Chem. 2003;100(1-3):159-70.
Chondroitin sulphate modification in the alpha4 chain of human recombinant laminin-8 (alpha4beta1gamma1). We have produced human laminin-8 (alpha4beta1gamma1) using recombinant...	26th April, 2003	BioStratum AB, 17177 Stockholm, Sweden.	Matrix Biol. 2002 Oct;21(6):483-6.
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. Laminins are alphabetagamma heterotrimeric extracellular proteins that...	22nd April, 2003	Department of Medical Biochemistry and Biophysics, Karolinska Institute	Blood. 2003 Feb 1;101(3):877-85. Epub 2002 Sep 19. DOI Direct Link

BioStratum Incorporated Clinical Trials:
Effect of Pyridorin in Patients With Diabetic Nephropathy

BioStratum Incorporated Patents:
US Patent No.	Title
7214799	Methods for the synthesis of pyridoxamine
7105291	Nephrin gene and protein
6955924	Laminin chains: diagnostic uses
6703363	Recombinant laminin 5
6689090	Perfusion apparatus and methods for pharmaceutical delivery
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