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Biotica Technology Ltd.Biotica Technology Limited ('Biotica', 'the Company') is a privately held UK biotechnology company focused on the discovery of novel polyketide pharmaceuticals through the targeted alteration of polyketide biosynthetic pathways. Its proprietary synthetic biology platforms enable both the specific and combinatorial biosynthesis of bioactive polyketides. Polyketides are a diverse class of natural products that have been a prolific source of commercially significant pharmaceuticals, currently representing worldwide sales in excess of $20 billion pa. The Company applies its technology platform to discover polyketides that are potentially useful therapeutics for the treatment of cancer and other diseases.
| Contact Details: |
| Chesterford Research ParkLittle Chesterford |
| Nr Saffron Walden |
| Essex |
| CB10 1XL |
| United Kingdom |
| Tel: | 44 (0)1799 532936 |
| Fax: | 44 (0)1799 532932 |
| Email: | info@biotica.com |
| WWW: | www.biotica.co.uk/

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Recent Publications by Biotica Technology Ltd.: |  |
Glycosylation engineering of spinosyn analogues containing an L-olivose moiety.
Biosynthetic genes encoding proteins involved in the first steps of... | 1st July, 2009
| Biotica Technology Ltd, Chesterford Research Park, Cambridge, UK CB10 1XL.
| Org Biomol Chem. 2009 Apr 21;7(8):1705-8. Epub 2009 Mar 12.
DOI Direct Link |
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
The glycosylation of natural product scaffolds with highly modified... | 5th November, 2008
| Biotica Technology Ltd, Chesterford Research Park, Little Chesterford,
| Org Biomol Chem. 2008 Sep 21;6(18):3315-27. Epub 2008 Jul 28.
DOI Direct Link |
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
A biosynthetic medicinal chemistry approach was applied to the... | 10th October, 2008
| Biotica Technology Limited, Chesterford Research Park, Nr. Saffron Walden,
| J Med Chem. 2008 Sep 25;51(18):5494-7.
DOI Direct Link |
Molecular characterization of macbecin as an Hsp90 inhibitor.
Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being... | 10th July, 2008
| Biotica Technology Limited, Chesterford Research Park, Essex CB10 1XL,
| J Med Chem. 2008 May 8;51(9):2853-7. Epub 2008 Mar 22.
DOI Direct Link |
Drug discovery beyond the 'rule-of-five'.
Although a very useful guideline for orally bioavailable small-molecule... | 15th May, 2008
| Biotica Technology Ltd., Chesterford Research Park, Little Chesterford nr
| Curr Opin Biotechnol. 2007 Dec;18(6):478-88. Epub 2007 Nov 26.
DOI Direct Link |
→View more Biotica Technology Ltd. research publications. |
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