DanioLabs (Cambridge UK) is a therapeutics company that has two primary business streams:
Internal R&D investigating new uses for established drugs (Reprofiling)
Phenotypic evaluation of compounds for other organisations, either for activity effects, or for preclinical safety pharmacology
As part of our approach, we use zebrafish as a key enabling technology. zebrafish as an experimental species provides significant benefits in the drug discovery process. They produce tiny, transparent offspring, that share some significant physiological and pharmacological similarities to humans, not least that they are vertebrates. Their size allows them to be used to evaluate the effects of compounds in human disease models in 96 well plate format. Therefore, medium throughput, high content in vivo assays are possible.
| Contact Details: |
| 7330 Cambridge Research Park |
| Cambridge |
| Cambridgeshire |
| CB5 9TN |
| United Kingdom |
| Tel: | 44(0)1223 706460 |
| Fax: | |
| Email: | info@daniolabs.com |
| WWW: | www.DANIOLABS.COM/
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Recent Publications by DanioLabs Ltd: |  |
Non-associative learning in larval zebrafish.
Habituation, where a response is reduced when exposed to a continuous... | 2nd August, 2008
| DanioLabs Ltd (a wholly owned subsidiary of VASTox plc), Unit 7330,
| Neuropsychopharmacology. 2008 Apr;33(5):1206-15. Epub 2007 Jun 20.
DOI Direct Link |
GBR12909 possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but cardiac ion channel effects limit its clinical utility.
BACKGROUND/AIMS: GBR12909 has been reported to possess anticonvulsant... | 6th December, 2007
| DanioLabs
| Pharmacology. 2007;79(4):250-8. Epub 2007 Apr 27.
DOI Direct Link |
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
The search for novel anticonvulsants requires appropriate model systems in... | 19th August, 2007
| DanioLabs Ltd., 7330 Cambridge Research Park, Cambridge CB25 9TN, UK.
| Epilepsy Res. 2007 Jun;75(1):18-28. Epub 2007 May 7.
DOI Direct Link |
A rapid, high content, in vivo model of glucocorticoid-induced osteoporosis.
Glucocorticoid-induced osteoporosis (GIOP) is a major clinical problem... | 9th December, 2006
| DanioLabs Ltd, Cambridge, UK.
| Biotechnol J. 2006 Jun;1(6):651-5.
DOI Direct Link |
High-throughput in vivo screening for bone anabolic compounds with zebrafish.
Osteoporosis and diseases of bone loss are a major public health problem... | 19th May, 2006
| DanioLabs
| J Biomol Screen. 2005 Dec;10(8):823-31. Epub 2005 Oct 18.
DOI Direct Link |
→View more DanioLabs Ltd research publications. |
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