Affinium Pharmaceuticals

Affinium Pharmaceuticals is a specialty pharmaceutical company focused on the discovery, development and commercialization of novel anti-infective medicines. AFN-1252 utilizes a unique mechanism of action by directly inhibiting the function of the bacterial fatty acid synthesis (FAS) II pathway. Affinium’s FASII antibacterial programs constitute a new antibiotic franchise with the potential for multiple products targeting the FASII pathway. These programs include a broad base of long-term intellectual property: issued and pending composition of matter patents on potent orally available small molecule inhibitors of a new class of antibiotics with a unique mechanism of action, targeting an underexploited pathway and are not subject to resistance selection pressures caused by the use of existing broad spectrum antibiotics.

Contact Details: 1243 Islington Ave., Suite 600 Toronto Ontario M8X 1Y9 Canada Tel: 416-645-6613 Fax: 416-646-1553 Email: oroberts@afnm.com WWW: www.afnm.com/

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Recent Publications by Affinium Pharmaceuticals:
Expression profiling of herpesvirus and vaccinia virus proteins using a high-throughput baculovirus screening system. We have developed a high-throughput system for generating baculoviruses...	9th February, 2006	Affinium Pharmaceuticals, Toronto, Canada.	J Proteome Res. 2005 Nov-Dec;4(6):2225-35. DOI Direct Link
The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa. Type II fatty acid biosynthesis systems are essential for membrane...	3rd February, 2005	Affinium Pharmaceuticals, Toronto, Ontario M5J 1V6, Canada.	J Biol Chem. 2004 Dec 10;279(50):52593-602. Epub 2004 Sep 14. DOI Direct Link
Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis. Triclosan MIC determination showed that recent Staphylococcus aureus...	25th May, 2004	Affinium Pharmaceuticals, Inc., Toronto, Ontario M5J 1V6, Canada.	Antimicrob Agents Chemother. 2004 Apr;48(4):1397-9.
High-throughput protein crystallization. High-throughput structural biology is a focus of a number of academic and...	10th February, 2004	Affinium Pharmaceuticals, 100 University Avenue, Ont., Toronto, Canada.	J Struct Biol. 2003 Apr;142(1):154-61.
Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens. Protein crystallization is a major bottleneck in protein X-ray...	23rd July, 2003	Affinium Pharmaceuticals Inc., Toronto, Ontario, Canada.	Proteins. 2003 Jun 1;51(4):562-8. DOI Direct Link
→View more Affinium Pharmaceuticals research publications.

BioNews Results for Affinium Pharmaceuticals:
MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the Ameri	KOTA Territory News:  Jun 29 2008 2:17AM Matching: pharmaceuticals
Synovics Pharmaceuticals forms a Strategic Joint Venture with Maneesh Pharmaceuticals	NewsRX:  Jun 29 2008 2:15AM Matching: pharmaceuticals
MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the Ameri	TickerTech.com:  Jun 28 2008 2:12PM Matching: pharmaceuticals
MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the Ameri	Twin Cities Business Journal:  Jun 28 2008 6:23PM Matching: pharmaceuticals
MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the Ameri	San Francisco Business Times:  Jun 28 2008 2:45PM Matching: pharmaceuticals
Promote your company here: BioNewsCast - Press Release Distribution	→View more Affinium Pharmaceuticals news.

Affinium Pharmaceuticals Patents:
US Patent No.	Title
7250424	Fab I inhibitors
6673941	Disubstituted imidazoles useful in the treatment of bacterial infections
6730684	Fab I inhibitors
6753172	FabI
6762201	Fab I inhibitors
→View more Affinium Pharmaceuticals patents.

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