Epigenomics seeks to use its DNA methylation technologies to develop the leading molecular diagnostics products and solution,improving the prognosis of cancer and other common diseasesMolecular diagnostics is a multi-billion euro market opportunity with the greatest future growth expected to be driven by oncology tests. We follow an integrated strategy and business model of partnering our blood-based screening tests and development of our own tissue-based molecular diagnostic products in our SBU Diagnostics. Clinical Solutions offers integrated biomarker solutions, and we aim at establishing a gold standard in DNA methylation via out-licensing.
Own product development & commercialization. The primary focus of product development will be two tissue-based tests directed at prostate and breast cancer molecular classification, leveraging DNA methylation markers and assays that already have significant clinical validation.
Our strategy for own product development builds on creating the organizational infrastructure and developing the required expertise inhouse. Its based on having full control over the entire process of clinical validation and clinical development, as well as regulatory approval, and positioning of the products. At the same time, we expect to work closely with OEM (original equipment manufacturing) partners for key components of our overall product. Both the patient sample processing kits as well as the IVD testing devices will be manufactured for Epigenomics.
| Contact Details: |
| Silke Peitsch, VP Human Resources |
| Kleine Präsidentenstr 1 |
| Berlin |
| 10178 |
| Germany |
| Tel: | 49 30 24345-0 |
| Fax: | 49 30 24345-555 |
| Email: | careers@epigenomics.com |
| WWW: | www.epigenomics.com/
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Recent Publications by Epigenomics AG: |  |
Multicenter Study Using Paraffin-Embedded Tumor Tissue Testing PITX2 DNA Methylation As a Marker for Outcome Prediction in Tamoxifen-Treated, Node-Negative Breast Cancer Patients.
PURPOSE: We recently reported DNA methylation of the paired-like... | 20th August, 2008
| Departments of Obstetrics and Gynecology and Pathology, Technical
| J Clin Oncol. 2008 Aug 18.
DOI Direct Link |
Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer.
Although transcriptional control is key for proper lung development,... | 29th July, 2008
| Epigenomics AG, Kleine Prasidentstrasse 1, 10178 Berlin, Germany.
| Int J Biochem Cell Biol. 2008;40(8):1494-508. Epub 2007 Dec 7.
DOI Direct Link |
DNA methylation profiling of pseudogene-parental gene pairs and two gene families.
A substantial proportion of human genes contain tissue-specifically... | 8th July, 2008
| Epigenomics AG, Kleine Prasidentstrasse 1, 10178 Berlin, Germany.
| Genomics. 2008 Jun;91(6):492-502. Epub 2008 May 2.
DOI Direct Link |
[Multiplexed methylation analysis--a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast]
AIMS: DNA methylation has been shown to play an important role in breast... | 30th April, 2008
| Epigenomics AG, Berlin.
| Verh Dtsch Ges Pathol. 2007;91:197-207.
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DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.
Background In this study, we evaluated if PITX2 DNA methylation is a... | 30th October, 2007
| Department of Biomedical Research and Development and Technology
| Breast Cancer Res Treat. 2008 Oct;111(3):429-37. Epub 2007 Oct 28.
DOI Direct Link |
→View more Epigenomics AG research publications. |
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