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F2G LtdF2G is advancing its own patented compounds and technologies which will lead to the development of novel agents to treat serious fungal disease.
The Company was founded on its proprietary genomics technology (MycoBank®) that identifies essential gene targets in fungi. Having received initial funding in 2002 the company then rapidly diversified into chemistry-driven discovery. We have also assembled an experienced development capacity. Our complementary approaches of robotic-based whole-cell-screens and enzyme-based high throughput screens assessing genes identified via MycoBank and using our diverse compound library of more than 360,000 compounds has delivered a portfolio of molecules into our drug development processes. Currently we have one series active against important moulds with preliminary evidence of activity in vivo and other chemical series active against a broader spectrum of fungi. Numerous essential fungal genes are also being assessed as targets for anti-fungal action. This progress has been delivered by our high-calibre staff using expertise in fungal molecular biology, biochemistry, clinical microbiology, animal pharmacology and medicinal chemistry. In late 2004 our Target Product Profiles were shared with an international panel of anti-fungal physicians who readily agreed that such compounds are needed by the infectious disease community; additional market research has established that new anti-fungal therapies are financially highly attractive. The F2G science team is supported by a management group which brings many years of experience from the world of finance and the Pharmaceutical Industry.
| Contact Details: |
| PO Box 1Lankro Way |
| Eccles |
| Manchester |
| M30 0BH |
| United Kingdom |
| Tel: | 44 (0)161 785 1270 |
| Fax: | 44 (0)161 785 1273 |
| Email: | contact@f2g.com |
| WWW: | www.f2g.com/
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Recent Publications by F2G Ltd: |  |
Characterisation of Aft1 a Fot1/Pogo type transposon of Aspergillus fumigatus.
In recent years the filamentous fungus Aspergillus fumigatus has become a... | 20th February, 2008
| F2G Ltd, Lankro Way, Eccles, Manchester M30 OBH, UK; The University of
| Fungal Genet Biol. 2008 Feb;45(2):117-26. Epub 2007 Oct 23.
DOI Direct Link |
The Aspergillus fumigatus cellobiohydrolase B (cbhB) promoter is tightly regulated and can be exploited for controlled protein expression and RNAi.
The utility of the Aspergillus fumigatus cellobiohydrolase cbhB promoter... | 31st January, 2007
| F2G Ltd, Lankro
| FEMS Microbiol Lett. 2006 Nov;264(2):246-54. Epub 2006 Sep 19.
DOI Direct Link |
Two families of extracellular phospholipase C genes are present in aspergilli.
Fungi secrete extracellular enzymes to enable them to harvest nutrients... | 30th January, 2007
| F2G Ltd, Lankro
| Mycol Res. 2006 Oct;110(Pt 10):1140-51. Epub 2006 Oct 2.
DOI Direct Link |
ADAMs are present in fungi: identification of two novel ADAM genes in Aspergillus fumigatus.
The ADAMs are a family of integral membrane proteases involved in shedding... | 26th October, 2005
| F2G Ltd., P.O. Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK.
| FEMS Microbiol Lett. 2005 Jul 1;248(1):23-30.
DOI Direct Link |
The rapid assignment of ruminal fungi to presumptive genera using ITS1 and ITS2 RNA secondary structures to produce group-specific fingerprints.
Identification of microbial community members in complex environmental... | 19th July, 2005
| F2G Ltd, Lankro Way, Eccles, Manchester M30 0BH, UK.
| Microbiology. 2005 May;151(Pt 5):1557-67.
DOI Direct Link |
→View more F2G Ltd research publications. |
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