Genstruct

Founded in 2002 by Navin Chandra, Noubar Afeyan and Keith Elliston, Genstruct is a privately held knowledge-driven systems biology company focused on pioneering new approaches to better understand and treat complex diseases. Dedication to Excellence Genstruct has continued to advance the analysis and application of high-throughput biology for the purpose of elucidating mechanisms, predicting safety, understanding efficacy, stratifying diseases and differentiating patients. By applying our proprietary technology, knowledge and methodologies, we have discovered novel mechanisms of action (MOA), as well as mechanism-based targets and biomarkers for diseases and compounds. Our Knowledge Assembly® models, mechanisms, hypotheses and biomarkers greatly enhance our partners' competitive advantage by enabling greater value creation through better and

Contact Details: One Alewife Center Cambridge Massachusetts 02140 United States of America Tel: (617) 547-5421 Fax: (617) 547-5442 Email: info@genstruct.com WWW: www.genstruct.com/

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Recent Publications by Genstruct:
The Role of Hypoxia in 2-Butoxyethanol-induced Hemangiosarcoma. To understand the molecular mechanisms underlying compound-induced...	9th October, 2009	Genstruct Inc., Cambridge, MA 02140.	Toxicol Sci. 2009 Oct 7. DOI Direct Link
SIRT1 promotes differentiation of normal human keratinocytes. Sir2 regulates lifespan in model organisms, which has stimulated interest...	7th January, 2009	Genstruct Inc., One Alewife Center, Cambridge, Massachusetts 2140, USA.	J Invest Dermatol. 2009 Jan;129(1):41-9. Epub 2008 Jun 19. DOI Direct Link
Computational causal reasoning models of mechanisms of androgen stimulation in prostate cancer. Sir2 regulates lifespan in model organisms, which has stimulated interest...	7th March, 2008	Genstruct	Conf Proc IEEE Eng Med Biol Soc. 2006;1:38. DOI Direct Link
Applying a causal framework to system modeling. The emerging field of systems biology represents a revolution in our...	16th February, 2007	Genstruct., Inc., One Alewife Center, Cambridge, MA 02140, USA.	Ernst Schering Res Found Workshop. 2007;(61):139-52.
A computational model to define the molecular causes of type 2 diabetes mellitus. BACKGROUND: Metabolic abnormalities associated with type 2 diabetes...	28th July, 2005	Genstruct, Inc., Cambridge, Massachusetts 02140, USA.	Diabetes Technol Ther. 2005 Apr;7(2):323-36. DOI Direct Link
→View more Genstruct research publications.

Press Releases on Genstruct:
Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting	14th April, 2009	Genstruct	DENVER and CAMBRIDGE, Mass., April 14 /PRNewswire/ -- (AACR 100th Annual Meeting 2009) - Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers
Genstruct and Gene Logic Collaborate on Systems Toxicology	25th February, 2009	Genstruct Inc.	SAN FRANCISCO, CAMBRIDGE, Mass. and GAITHERSBURG, Md., Feb. 25 /PRNewswire/ -- (CHI's Molecular Medicine Tri-Conference) - Genstruct Inc., a systems biology company focused on identifying
Genstruct Added to The Biomarker Consortium's Rapidly Growing Roster of Industry Experts	4th November, 2008	Genstruct Inc.	CAMBRIDGE, Mass., Nov. 4 /PRNewswire/ -- Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers to better develop novel therapeutics and
Genstruct Expands Team with New VP of Engineering	20th October, 2008	Genstruct, Inc.	CAMBRIDGE, Mass., Oct. 20 /PRNewswire/ -- Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers to better understand large-scale biology,

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