Gentronix is an innovative biotechnology company helping to accelerate the pace of drug development in the pharmaceutical industry. Gentronix is developing a range of productivity-enhancing tools for scientists in the drug discovery field, designed to ease or remove current bottlenecks in pre-clinical research and development.
Gentronix's first product release, GreenScreenŽ, successfully combines our expertise in molecular biology and analytical science to address the ADMET bottleneck in lead candidate selection, focusing specifically on genotoxicity screening. GreenScreenŽ products are for use in genetic toxicity screening and can contribute to the selection of lead collections enriched with compounds lacking genotoxicity. A variation of the GreenScreen technology has also been developed for environmental monitoring.
Gentronix Ltd was established in July 1999 to commercialise technology developed jointly in the departments of Biomolecular Sciences and Instrumentation & Analytical Science at UMIST (University of Manchester Institute of Science and Technology) in the UK.
| Contact Details: |
| The Manchester Incubator Building48 Grafton Street |
| Manchester |
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| M13 9XX |
| United Kingdom |
| Tel: | 44 (0) 161 606 7268 |
| Fax: | 44 (0) 161 606 7337 |
| Email: | peter.mcculloch@gentronix.co.uk |
| WWW: | www.gentronix.co.uk/
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Recent Publications by Gentronix Limited: |  |
Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals.
Three high-throughput screening (HTS) genotoxicity assays-GreenScreen HC... | 14th July, 2009
| Gentronix Ltd., CTF Building, Manchester, M13 9NT, UK.
| Regul Toxicol Pharmacol. 2009 Nov;55(2):188-99. Epub 2009 Jul 8.
DOI Direct Link |
Development and validation of a higher throughput screening approach to genotoxicity testing using the GADD45a-GFP GreenScreen HC assay.
There is a pressing need to develop rapid yet accurate screening assays... | 23rd May, 2009
| Gentronix
| J Biomol Screen. 2009 Jan;14(1):16-30.
DOI Direct Link |
Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay.
Genotoxicity can be assessed by monitoring expression of a GADD45a-GFP... | 16th January, 2009
| Gentronix Ltd, Manchester, UK.
| Mutagenesis. 2009 Jan;24(1):35-50. Epub 2008 Sep 11.
DOI Direct Link |
Genotoxic carcinogen or not genotoxic carcinogen? That is the question Re: Olaharski et al., "Validation of the GreenScreen GADD45alpha-GFP indicator assay with non-proprietary and proprietary compounds".
There is a pressing need to develop rapid yet accurate screening assays... | 13th November, 2008
| University of Manchester, Faculty of Life Sciences, Manchester M13 9NT,
| Mutat Res. 2009 Jan 10;672(1):17-9. Epub 2008 Oct 19.
DOI Direct Link |
GADD45a-GFP GreenScreen HC genotoxicity screening assay.
BACKGROUND: Genetic toxicology is getting very interesting. The... | 31st October, 2008
| Gentronix Ltd, CTF Building, 46 Grafton Street, Manchester M13 9NT, UK.
| Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):827-35.
DOI Direct Link |
→View more Gentronix Limited research publications. |
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Gentronix Limited
