Inotek Pharmaceuticals Corporation

Inotek Pharmaceuticals Corporation is a private, high-growth, development-stage pharmaceutical firm founded in 1996. The Company has a deep and diverse pipeline with seven products in pre-clinical or clinical development targeting oncology, cardiovascular and inflammatory diseases. The Company is pursuing indications in hospital cardiovascular markets as well as specialty care markets including dermatology, gastroenterology and oncology. All of the Company's technologies were discovered and developed by Inotek researchers. The Company currently has more than 120 employees, based in its headquarters and main laboratories in Beverly, Massachusetts and its clinical operations and GMP manufacturing facilities in Israel

Contact Details: 100 Cummings Center4th Floor Beverly Massachusetts 01915 United States of America Tel: 978-232-9660 Fax: 978-232-8975 Email: info@inotekcorp.com WWW: www.inotekcorp.com/

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Recent Publications by Inotek Pharmaceuticals Corporation:
Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one. [reaction: see text] The synthesis of...	10th February, 2006	Inotek Pharmaceuticals Corporation, 100 Cummings Center, Beverly,	Org Lett. 2005 Apr 28;7(9):1753-6. DOI Direct Link
Mechanisms of cell necrosis. OBJECTIVE: Rotigotine (Neupro) is formulated as a transdermal delivery...	19th January, 2006	Inotek Pharmaceuticals Corporation, Beverly, MA, USA.	Crit Care Med. 2005 Dec;33(12 Suppl):S530-4.
Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. Activation of poly(ADP-ribose) polymerase (PARP) is an important factor in...	13th January, 2006	Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA.	J Pharmacol Exp Ther. 2005 Nov;315(2):812-20. Epub 2005 Aug 3. DOI Direct Link
Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. OBJECTIVE: The stimulation of epithelial cells by cytokines or...	3rd November, 2005	Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E,	Inflamm Res. 2004 Nov;53(11):604-8.
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Angiotensin II (AII) contributes to the pathogenesis of many...	20th October, 2005	Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center,	Mol Med. 2004 Jan-Jun;10(1-6):28-35.
→View more Inotek Pharmaceuticals Corporation research publications.

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Inotek Pharmaceuticals Corporation Patents:
US Patent No.	Title
7432369	Pyridyl-substituted porphyrin compounds and methods of use thereof
6828319	Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof
6903079	Nucleoside compounds and compositions thereof
6956035	Isoquinoline derivatives and methods of use thereof
6958324	Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
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