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EMD Lexigen Research CenterEMD Lexigen Research Center Corp. Founded in 1992 as a joint venture with Fuji Photo Film Ltd., EMD Lexigen Research Center Corp. (EMD Lexigen for short) was formed to screen Fuji’s chemical library for drug activities, with an initial focus on immune disorders and cancer.
Our activities have evolved significantly since then. Having gained independence from Fuji Photo Film in 1997, EMD Lexigen has honed its activities to focus on developing proprietary immunocytokine and Fc-X fusion protein technologies for treatment of life-threatening diseases such as cancer and AIDS.
EMD Lexigen’s innovative technology and approach to oncology quickly drew the attention of the pharmaceutical community, including Merck KGaA, Darmstadt, Germany, which ultimately acquired EMD Lexigen in 1999.
EMD Lexigen is a subsidiary of Merck KGaA, Darmstadt, Germany. Our research center, located in the Route 128 Biotech Corridor near Boston, Mass., is the hub for Merck KGaA’s biological pharmaceutical research activities, emphasizing advanced pharmaceutical platform technologies and novel drugs.
With access to the Boston area’s rich combination of world-class academic and research institutions and highly skilled workforce, we have built a company that thrives on innovation, with employees dedicated to improving people’s lives.
| Contact Details: |
| 45A Middlesex Turnpike |
| Billerica |
| Massachusetts |
| 01821 |
| United States of America |
| Tel: | 978 294 1100 |
| Fax: | 978 294 1101 |
| Email: | info@emdlexigen.com |
| WWW: | www.lexigenpharm.com/
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Recent Publications by EMD Lexigen Research Center: |  |
huBC1-IL12, an immunocytokine which targets EDB-containing oncofetal fibronectin in tumors and tumor vasculature, shows potent anti-tumor activity in human tumor models.
IL-12 is a cytokine which showed anti-tumor effects in clinical trials,... | 17th May, 2007
| EMD Lexigen Research Center, 45A Middlesex Turnpike, Billerica, MA 01821,
| Cancer Immunol Immunother. 2007 Apr;56(4):447-57. Epub 2006 Jul 28.
DOI Direct Link |
Engineering a pharmacologically superior form of leptin for the treatment of obesity.
Leptin plays a central role in the homeostasis of body weight through its... | 28th October, 2005
| EMD-Lexigen Research Center, Bedford Campus, 45A Middlesex Turnpike,
| Protein Eng Des Sel. 2005 Jan;18(1):1-10.
DOI Direct Link |
Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond.
Erythropoietin (Epo) is a cytokine that controls the production of red... | 4th October, 2005
| EMD Lexigen Research Center Corp., 45A Middlesex Turnpike, Billerica, MA
| Protein Eng Des Sel. 2005 Mar;18(3):111-8. Epub 2005 Apr 8.
DOI Direct Link |
An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma.
We have engineered an anti-CD20-interleukin 2 (IL-2) immunocytokine (ICK)... | 9th June, 2005
| EMD Lexigen Research Center, Bedford Campus, 45A Middlesex Tpk, Billerica,
| Blood. 2005 May 15;105(10):3972-8. Epub 2005 Feb 3.
DOI Direct Link |
Immunocytokines: amplification of anti-cancer immunity.
Many cancers elicit an anti-tumor immune response, which is nevertheless... | 26th June, 2003
| EMD Lexigen Research Center, Billerica, MA 01821, USA.
| Cancer Immunol Immunother. 2003 May;52(5):297-308. Epub 2003 Jan 31.
DOI Direct Link |
→View more EMD Lexigen Research Center research publications. |
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