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Center of Molecular ImmunologyThe Center of Molecular Immunology (CIM) is a Cuban Biotechnological Institution devoted to basic research, product development and production of mammalian cell culture products such as monoclonal antibodies and recombinant proteins. CIM’s research goals focus on cancer and immune system related disorders.
The 15 000 m2 two floor facility has a cGMP production area designed for maximum product protection. Hollow fiber and stirred tank fermenters are used in upstream production. The facility has an annual production capacity of several kilograms of the purified product.
Our long range R&D activities enable us to innovate and create intellectual property for the development of new products. These include antibody engineering, glycobiology, computer assisted molecular modeling and idiotipic regulation of the immune system. Basic research projects are focused on immunotherapy of
autoimmune diseases and cancer especially the development of cancer vaccines.
Different products obtained and produced at CIM are currently distributed in Cuba and abroad by CIMAB S.A., CIM’s exclusive representative. These include products for the treatment of patients with organ transplant rejection and anemia and for tumor imaging. Additionally CIMAB S.A. is engaged in establishing corporate alliances for the joint development of CIM’s pipeline of projects in the fields of:autoimmune diseases such as Psoriasis and Rheumatoid arthritis;Tumor imaging;Cancer therapy by radioimmunotherapy, passive immunotherapy and active immunotherapy based on molecular and anti idiotipic vaccines.
| Contact Details: |
| 216 esq. 15 Atabey, Playa |
| Havana |
| Havana |
| 11600 |
| Cuba |
| Tel: | 53-7 21 4335 |
| Fax: | 53-7 33 3509 |
| Email: | blanca@ict.cim.sld.cu |
| WWW: | www.cim.sld.cu/
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Recent Publications by Center of Molecular Immunology: |  |
Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody.
N-Glycolylated (NeuGc) gangliosides are tumor-specific antigens and as... | 21st October, 2009
| Center of Molecular Immunology, Havana, Cuba.
| Mol Immunol. 2009 Oct;46(16):3466-75. Epub 2009 Sep 12.
DOI Direct Link |
Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation.
Overexpression of the epidermal growth factor (EGF) receptor (EGFR) in... | 26th September, 2009
| Center of Molecular Immunology, Havana, Cuba.
| Cancer Res. 2009 Jul 15;69(14):5851-9. Epub 2009 Jul 7.
DOI Direct Link |
Spatial analysis of breast and cervical cancer incidence in small geographical areas in Cuba, 1999-2003.
According to the data from the National Cancer Registry, breast and... | 16th September, 2009
| Section of Data Management and Biostatistics, Clinical Trials Department,
| Eur J Cancer Prev. 2009 Sep;18(5):395-403.
DOI Direct Link |
Autoantibodies to oxidized low density lipoprotein in relation with coronary artery disease.
The relationship between autoantibodies (autoAbs) to oxidized LDL (oxLDL)... | 5th September, 2009
| Center of Molecular Immunology, Havana, Cuba.
| Hum Antibodies. 2009;18(3):109-17.
DOI Direct Link |
Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine.
Cancer vaccines efficacy may improve inducing a rapid and persistent... | 19th June, 2009
| Experimental Immunotherapy Department, Center of Molecular Immunology, 216
| Vaccine. 2009 Apr 6;27(16):2230-9. Epub 2009 Feb 13.
DOI Direct Link |
→View more Center of Molecular Immunology research publications. |
Press Releases on Center of Molecular Immunology:
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| YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB RESULTS IN ADVANCED TRIPLE-NEGATIVE BREAST CANCER MODEL PRESENTED AT AACR-NCI-EORTC MEETING |
18th November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 18 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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| YM BIOSCIENCES REPORTS CYT997 ORAL VASCULAR DISRUPTING AGENT RESULTS PRESENTED AT AACR-NCI-EORTC MEETING |
17th November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 17 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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| YM BIOSCIENCES REPORTS FISCAL FIRST QUARTER 2010 OPERATIONAL AND FINANCIAL RESULTS |
11th November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 11 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI, TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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| YM BIOSCIENCES REPORTS POSITIVE NIMOTUZUMAB FOUR-YEAR SURVIVAL DATA PRESENTED AT ASTRO 2009 |
2nd November, 2009 |
YM BioSciences Inc. |
- Follow-On Results from a Randomized Phase IIb Head & Neck Trial
Demonstrate Efficacy of Nimotuzumab Without Severe, Class-Associated
Toxicities -
MISSISSAUGA, ON, Nov. 2
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| YM BIOSCIENCES REPORTS ADDITIONAL RESULTS FROM NIMOTUZUMAB PHASE III STUDY IN CHILDREN WITH GLIOMA PRESENTED BY ONCOSCIENCE AG |
29th October, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Oct. 29 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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