|
| |
MethylGene Inc.MethylGene is a publicly-traded biopharmaceutical company listed on the Toronto Stock Exchange under the symbol MYG. We focus in the areas of cancer, infectious disease and other diseases such as diabetes, Huntington's and inflammation. We currently have two drugs in development being tested in human clinical trials: MGCD0103 and MG98. Our strategy is to partner our programs to complement our business objectives. We have successfully partnered with MGI Pharma, Taiho Pharmaceutical, Pharmion Corporation, Merck and EnVivo Pharmaceuticals.MethylGene's experienced in-house medicinal chemistry group is able to develop drugs that specifically target enzymes that are involved in certain diseases such as cancer. We do this by understanding the characteristics of the enzyme involved in the disease and then creating a molecule that will specifically inhibit that enzyme from functioning. In this way, the enzyme may be controlled. Once we have a set of lead molecules, we have a seasoned biology team test our candidate drugs in animal models. Molecules that have the desired profile become clinical candidates and are eventually tested in human clinical trials.
The advantage of having drugs that are specific to their target is that they should only affect diseased cells leaving healthy cells untouched. This is in contrast to other approaches such as chemotherapy or radiation therapy where both healthy and diseased cells are affected causing unnecessary side effects.
| Contact Details: |
| 7220 Frederick-Banting |
| Montreal |
| Quebec |
| H4S 2A1 |
| Canada |
| Tel: | 514.337.3333 |
| Fax: | |
| Email: | info@methylgene.com |
| WWW: | www.methylgene.com/
|
|
Loading...
|
Recent Publications by MethylGene Inc.: |  |
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylim idazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
A series of... | 27th October, 2009
| Department of Medicinal Chemistry, MethylGene Inc, Montreal, QC, Canada.
| Bioorg Med Chem Lett. 2009 Dec 1;19(23):6552-6. Epub 2009 Oct 13.
DOI Direct Link |
1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).
We have identified the N(1)-benzyl-N(2)-methylethane-1,2-diamine unit as a... | 20th October, 2009
| Department of Medicinal Chemistry, MethylGene Inc, Montreal, Quebec,
| Bioorg Med Chem Lett. 2009 Dec 1;19(23):6725-32. Epub 2009 Oct 2.
DOI Direct Link |
Combination Testing of MGCD290, a Hos2 Histone Deacetylase Inhibitor, with Azole Antifungals against Opportunistic Fungal Pathogens.
We report the in vitro activity of the Hos2 fungal histone deacetylase... | 2nd October, 2009
| Departments of Pathology, Epidemiology, and Internal Medicine, Roy J. and
| J Clin Microbiol. 2009 Sep 30.
DOI Direct Link |
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylim idazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
A series of... | 29th August, 2009
| Department of Medicinal Chemistry, MethylGene Inc., 7220 rue
| Bioorg Med Chem Lett. 2009 Mar 1;19(5):1323-8. Epub 2009 Jan 27.
DOI Direct Link |
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
We have identified a series of diphenylmethylene hydroxamic acids as novel... | 25th August, 2009
| MethylGene Inc., Department of Medicinal Chemistry, 7220
| Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. Epub 2009 Aug 7.
DOI Direct Link |
→View more MethylGene Inc. research publications. |
 Contact BioPortfolio for a quote for a customised Excel verision of BioCorporate or BioEmail databases.
This page has been viewed 387 times since April 2007, the link to the organisation's website has been followed 66 times Search for more companies in Montreal Search for more companies in Quebec This site uses Thumbshots previews, resources from the NCBI applied. Maps are centred on zip/postcodes and should not be relied upon for exact building locations. Some information on this page has been collected automatically and may not have been verified.BioPortfolio search results for MethylGene Inc. |
