Molecular IsotopeTechnologies

Stable isotopes are non-radioactive chemical tracers that are relatively unexploited by the pharmaceutical industry as compared to the natural sciences. Stable isotope ratios are measured by combustion and mass spectrometric analyses of either bulk phases or specific compounds. Bulk phases are typically analyzed by either offline combustion followed by dual-inlet mass spectrometry or by online combustion coupled with isotope-ratio-monitoring/mass spectrometry (irmMS). Specific compounds are analyzed by either gas chromatography coupled with irmMS (irmGCMS) or by liquid chromatography coupled with irmMS (irmLCMS), depending on the chromatographic properties of the analytes. Jasper (1999, Pharm. Tech. 23(10)) reviews nine major points regarding the properties and uses of stable isotopes in the pharmaceutical industry, including the suggestion of "isotopic bar coding" of Active Pharmaceutical Ingredients (APIs) and drug products.

Contact Details: 8 Old Oak Lane Niantic Connecticut 06357 United States of America Tel: (860) 739-1926 Fax: (860) 739-3250 Email: JPJasper@MolecularIsotopes.com WWW: www.molecularisotopes.com/

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