ChemoCentryx

ChemoCentryx is a privately held biopharma company specializing in the biology of chemokines, protein hormones that regulate the migration, or trafficking, of white blood cells around the body. White cell (leukocyte) trafficking is an essential process, regulating our response to infection and inflammation. While chemokines are important for normal health, the chemokines (and their receptors) compose a balanced but complicated system that is linked to diseases as diverse as rheumatoid arthritis, atherosclerosis, multiple sclerosis, and even AIDS.

Contact Details: 1539 Industrial Road San Carlos CA 94070 United States of America Tel: 650-632-2900 Fax: 650-632-2910 Email: WWW: www.chemocentryx.com/

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Recent Publications by ChemoCentryx:
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act...	19th September, 2009	ChemoCentryx,	J Immunol. 2009 Sep 1;183(5):3204-11. Epub 2009 Jul 29. DOI Direct Link
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Chemokines and chemokine receptors have been posited to have important...	6th December, 2007	ChemoCentryx, Inc., Mountain View, CA 94043, USA.	Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15735-40. Epub 2007 Sep 26. DOI Direct Link
Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. Most chemokines have been found to bind to and signal through single or...	13th July, 2007	ChemoCentryx,	J Immunol. 2007 Jun 1;178(11):7395-404.
Evidence for NK cell subsets based on chemokine receptor expression. To help understand the role of chemokines in NK cell trafficking, we...	17th January, 2007	ChemoCentryx, 850 Maude Avenue, Mountain View, CA 94043, USA.	J Immunol. 2006 Dec 1;177(11):7833-40.
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. The chemokine stromal cell-derived factor (SDF-1; also known as chemokine...	9th November, 2006	ChemoCentryx, Inc., Mountain View, CA 94043, USA.	J Exp Med. 2006 Sep 4;203(9):2201-13. Epub 2006 Aug 28. DOI Direct Link
→View more ChemoCentryx research publications.

Press Releases on ChemoCentryx:
PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference	1st June, 2009	ChemoCentryx, Inc.	Oral CCR9 Antagonist Demonstrates Clinical Efficacy with Favorable Tolerability Profile MOUNTAIN VIEW, Calif., June 1 /PRNewswire/ -- ChemoCentryx, Inc., announced that Phase II/III clinical data
ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week	19th May, 2009	ChemoCentryx, Inc.	First-in-class Oral Therapeutic for IBD with Novel Mode of Action MOUNTAIN VIEW, Calif., May 19 /PRNewswire/ -- ChemoCentryx, Inc., today announced that data from the company's PROTECT-1 (the
ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist	5th May, 2009	ChemoCentryx, Inc.	Development Candidate Triggers Milestone Payment from GlaxoSmithKline MOUNTAIN VIEW, Calif., May 5 /PRNewswire/ -- ChemoCentryx, Inc., today announced that it has identified an orally
Solexa Names Linda Rubinstein Vice President And CFO	1st January, 1970	Solexa	Solexa Names Linda Rubinstein Vice President And CFO HAYWARD, Calif. (March 30, 2005) – Solexa, Inc. (NASDAQ: SLXA) today announced the

ChemoCentryx Clinical Trials:
A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn's Disease

ChemoCentryx Patents:
US Patent No.	Title
7589199	Substituted piperazines
7262204	Modulation of CCR4 function
7253007	Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
7227035	Bis-aryl sulfonamides
7157464	Substituted piperazines
→View more ChemoCentryx patents.

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