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Nabi BiopharmaceuticalsNABI Biopharmaceuticals are a biopharmaceutical company focused on the development of products that address unmet medical needs in the areas of nicotine addiction and infectious disease. We leverage our experience and knowledge in powering the human immune system to target serious medical conditions in these areas. Our lead products in development are NicVAX® [ Nicotine Conjugate Vaccine ], an innovative and proprietary investigational vaccine for treatment of nicotine addiction and prevention of smoking relapse, and StaphVAX® [ Staphylococcus aureus Vaccine ], a new pentavalent vaccine designed to prevent S.aureus infections including those infections caused by the most dangerous antibiotic-resistant strains of S.aureus .
NicVAX is an investigational vaccine based on patented technology. Nicotine, a small molecule, can cross the blood-brain barrier and reach specific receptors in the brain, thereby leading to the highly addictive pleasure sensation experienced by smokers and users of nicotine products. NicVAX is designed to stimulate the immune system to produce antibodies that bind to nicotine. A nicotine molecule attached to an antibody is too large to cross the blood-brain barrier, and thus is unable to reach the receptors in the brain and trigger pleasure sensations. In November 2007, we announced the successful completion of a Phase IIb “proof-of-concept” clinical trial for our NicVAX development program. The Phase IIb study showed statistically significant rates of smoking cessation and continuous long-term smoking abstinence at 6 and 12 months for subjects injected with NicVAX as compared with subjects injected with a placebo.
StaphVAX is an investigational vaccine based on patented technology, including technology that we have licensed on an exclusive basis from the National Institutes of Health, or NIH. We are developing StaphVAX for use in patients who are at high risk of S.aureus infection and who are able to respond to a vaccine by producing their own antibodies.
NicVAX and StaphVAX will require additional development, including preclinical testing and human studies for StaphVAX and additional human testing for NicVAX as well as regulatory approvals, before we can market them. We are continuing to develop NicVAX and StaphVAX while we search for partners who will assist in the further development and commercialization of these products.
| Contact Details: |
| 12276 Wilkins Ave |
| Rockville |
| MD |
| 20852 |
| United States of America |
| Tel: | 301-255-6803 |
| Fax: | 301-770-3097 |
| Email: | gfries@nabi.com |
| WWW: | www.nabi.com/
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Recent Publications by Nabi Biopharmaceuticals: |  |
Controversies in the management of hyperphosphatemia in patients with end-stage renal disease.
Quantum information theory establishes the ultimate limits on... | 4th May, 2006
| Medical Affairs Department, Nabi Biopharmaceuticals, Rockville, MD, USA.
| Manag Care. 2006 Mar;15(3 Suppl):5-8.
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Safety and immunogenicity of a booster dose of Staphylococcus aureus types 5 and 8 capsular polysaccharide conjugate vaccine (StaphVAX) in hemodialysis patients.
StaphVAX, an unadjuvanted, bivalent vaccine composed of Staphylococcus... | 25th May, 2005
| WW Karakawa Microbial Pathogenesis Laboratory, Nabi Biopharmaceuticals,
| Vaccine. 2004 Dec 16;23(5):656-63.
DOI Direct Link |
Development of StaphVAX, a polysaccharide conjugate vaccine against S. aureus infection: from the lab bench to phase III clinical trials.
Staphylococcus aureus is the most common nosocomial pathogen and is... | 28th April, 2004
| NABI Biopharmaceuticals, 12280 Wilkins Avenue, Rockville, MD 20852, USA.
| Vaccine. 2004 Feb 17;22(7):880-7.
DOI Direct Link |
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