Nuvelo

Nuvelo, Inc. is a publicly traded biopharmaceutical company dedicated to improving the lives of patients through the discovery, development and commercialization of novel drugs for acute cardiovascular and cancer therapy. Nuvelo's development pipeline includes several acute cardiovascular and oncology programs. The cardiovascular portfolio includes three programs: alfimeprase, a direct acting thrombolytic in development for the treatment of thrombotic- related disorders; rNAPc2, an anticoagulant that inhibits the factor VIIa and tissue factor protease complex, which completed a Phase 2 clinical trial in acute coronary syndromes; and preclinical candidate NU172, a direct thrombin inhibitor for use as a short-acting anticoagulant during medical procedures. The oncology portfolio includes two main programs: preclinical candidate NU206 for the potential treatment of chemotherapy/radiation therapy-induced mucositis and inflammatory bowel disease; and rNAPc2, which is in Phase 2 development for potential use as a cancer therapy. In addition, Nuvelo expects to leverage its expertise in secreted proteins and antibody discovery to expand its pipeline and create additional partnering and licensing opportunities.

Contact Details: 201 Industrial Road, Suite 310 San Carlos California 94070-6211 United States of America Tel: 650.517.8000 Fax: 650.517.8001 Email: ir@nuvelo.com WWW: www.nuvelo.com/

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Recent Publications by Nuvelo:
Argatroban Anticoagulation in Intensive Care Patients: Effects of Heart Failure and Multiple Organ System Failure. We retrospectively evaluated argatroban dosing patterns, clinical...	15th August, 2008	Nuvelo, Inc.	J Intensive Care Med. 2008 Aug 12. DOI Direct Link
R-spondin family members regulate the wnt pathway by a common mechanism. The R-Spondin (RSpo) family of secreted proteins is implicated in the...	11th April, 2008	Research Department, Nuvelo, San Carlos, CA 94070.	Mol Biol Cell. 2008 Jun;19(6):2588-96. Epub 2008 Apr 9. DOI Direct Link
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. The R-Spondin (RSpo) family of secreted proteins act as potent activators...	2nd November, 2007	Nuvelo, Inc., 201 Industrial Road, Suite 310, San Carlos, CA 94070-6211,	Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. Epub 2007 Sep 5. DOI Direct Link
The lymphoid cell surface receptor NTB-A: a novel monoclonal antibody target for leukaemia and lymphoma therapeutics. NTB-A is a CD2-related cell surface protein expressed primarily on...	19th June, 2007	Nuvelo,	Br J Haematol. 2007 May;137(4):307-18. DOI Direct Link
R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. BACKGROUND & AIMS: R-spondin 1 (Rspo1) is a novel epithelial mitogen that...	18th May, 2007	Department of Research, Nuvelo, Inc, San Carlos, California, USA.	Gastroenterology. 2007 Apr;132(4):1331-43. Epub 2007 Feb 6. DOI Direct Link
→View more Nuvelo research publications.

BioNews Results for Nuvelo:
Nuvelo reports positive results from Phase Ib anticoagulant drug trial	Pharmaceutical Business Review:  Aug 19 2008 1:17AM Matching: nuvelo
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172	KOTA Territory News:  Aug 15 2008 8:29AM Matching: nuvelo
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172	KLFY:  Aug 14 2008 5:34PM Matching: nuvelo
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172	KRON4:  Aug 14 2008 3:17PM Matching: nuvelo
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172	Therapeutics Daily:  Aug 14 2008 1:37PM Matching: nuvelo
Promote your company here: BioNewsCast - Press Release Distribution	→View more Nuvelo news.

Nuvelo Patents:
US Patent No.	Title
7411052	Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
6806254	Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides
6800443	Method of detecting a cancerous cell expressing an EGF motif polynucleotide
6787328	Methods and compositions relating to CD39-like polypeptides and nucleic acids
6783969	Cathepsin V-like polypeptides
→View more Nuvelo patents.

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