Oxagen Limited is focused on becoming a significant biopharmaceutical company, developing a pipeline of novel drugs to treat inflammatory diseases. The Company has created a portfolio of valuable drug targets centered on the highly attractive class of receptors, GPCRs. Through its heritage in human genetics, Oxagen has validated a number of GPCR targets, many of them novel, and selected the most promising as drug targets. The lead programme is to develop a small molecule to target a GPCR, designated
OG466. The lead molecule, ODC9101 inhibits the activity of OG466, offering the potential to treat asthma and other respiratory and inflammatory related conditions.
Oxagen is based near Oxford, UK. The Company has in-house preclinical and development staff managing a series of contract research relationships with outside suppliers in pre-clinical testing, medicinal and formulation chemistry and conduct of clinical trials.
Recently re-funded through a $60M investment round led by MPM Capital (see press release), Oxagen is a private company, founded in 1997 and financed by a group of high quality venture capital firms.
| Contact Details: |
| 91 Milton Park |
| Abingdon |
| Oxfordshire |
| OX14 4RY |
| United Kingdom |
| Tel: | 44(0) 1235 443300 |
| Fax: | 44(0) 1235 443301 |
| Email: | oxagen@oxagen.co.uk |
| WWW: | www.oxagen.co.uk/
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Recent Publications by Oxagen Limited: |  |
Antagonists of the prostaglandin D(2) receptor CRTH2.
Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and... | 7th October, 2008
| Oxagen
| Drug News Perspect. 2008 Jul-Aug;21(6):317-22.
DOI Direct Link |
Use of commercially available radiation hybrid panels.
Several panels are available for puchase, and this unit provides update... | 24th May, 2008
| Oxagen, Ltd., Abingdon, United Kingdom.
| Curr Protoc Hum Genet. 2001 May;Chapter 3:Unit 3.5.
DOI Direct Link |
The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.
Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and... | 29th April, 2008
| Oxagen Ltd, 91 Milton
| Br J Pharmacol. 2008 Mar;153 Suppl 1:S191-9. Epub 2007 Oct 29.
DOI Direct Link |
A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.
Activation of human CRTH2(+) CD4(+) T helper type 2 (Th2) cells with... | 31st August, 2007
| Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom.
| Immunology. 2007 Aug;121(4):577-84. Epub 2007 Apr 16.
DOI Direct Link |
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases.
Immunological activation of mast cells is an important trigger in the... | 9th May, 2007
| Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK.
| Nat Rev Drug Discov. 2007 Apr;6(4):313-25.
DOI Direct Link |
→View more Oxagen Limited research publications. |
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