Plexxikon Inc.

Plexxikon is a leader in the discovery and development of novel small molecule pharmaceuticals to treat human disease. Since operations commenced June 2001, Plexxikon has applied its proprietary platform technology to identify and build a portfolio of product opportunities for therapeutic indications in metabolic disorders, cardiovascular disease, inflammation and oncology.Current Plexxikon programs address disease targets that are already validated in humans, have clear clinical development paths for significant unmet markets, and demonstrate Plexxikon's capability to address side effects and/or enhance the therapeutic profile of current drug treatments.
Plexxikon's discovery process utilizes a number of technologies, including Plexxikon's Scaffold-Based Drug Discovery™ platform. This discovery platform involves structural screening and analysis as one key component providing a significant competitive advantage to other drug discovery approaches. Structural screening is applied at the earliest point in lead finding to address current challenges in pharmaceutical drug discovery today – by enabling the mining of novel chemical space, applying a unique quality filter, and by providing a roadmap for lead discovery and development chemistry.

Contact Details: 91 Bolivar Drive Berkeley California 94710 United States of America Tel: 510.647.4000 Fax: 510.548.8014 Email: info@plexxikon.com WWW: www.plexxikon.com/

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Recent Publications by Plexxikon Inc.:
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Cyclic nucleotide phosphodiesterases (PDEs) comprise a large family of...	1st June, 2005	Plexxikon Inc., 91 Bolivar Dr., Berkeley, California 94710, USA.	Nat Biotechnol. 2005 Feb;23(2):201-7. Epub 2005 Jan 30. DOI Direct Link
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. Phosphodiesterases (PDEs) comprise a family of enzymes that modulate the...	4th September, 2004	Plexxikon Inc., 91 Bolivar Drive, Berkeley, CA 94710, USA.	Mol Cell. 2004 Jul 23;15(2):279-86. DOI Direct Link
Raf pathway inhibitors in oncology. Recognition of the importance of the Raf pathway in the proliferation and...	23rd March, 2004	Plexxikon Inc., 91 Bolivar Drive, Berkeley, CA 94710, USA.	Curr Opin Investig Drugs. 2003 Dec;4(12):1436-41.

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Plexxikon Inc. Patents:
US Patent No.	Title
7348338	PPAR active compounds
7202266	PPAR active compounds

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