Prosidion Ltd

(OSI) Prosidion is the diabetes and obesity business group within OSI Pharmaceuticals, Inc. (NASDAQ:OSIP) dedicated to the discovery and development of novel drugs for the treatment of type 2 diabetes and obesity. (OSI) Prosidion's lead compound PSN9301 is a Dipeptidyl Peptidase IV (DP-IV) inhibitor currently in Phase II clinical trials. PSN357, a glycogen phosphorylase inhibitor, is undergoing Phase IIa clinical studies and PSN010, a glucokinase activator, has recently entered Phase I clinical trials. (OSI) Prosidion owns or has licensing rights to a portfolio of DP-IV medical use patents with claims covering DP-IV as a target for anti-diabetes therapy and the use of combinations of DP-IV inhibitors with other anti-diabetes drugs such as metformin. A number of non-exclusive licenses to the patent estate have been granted to major pharmaceutical companies. (OSI) Prosidion operates through OSI's wholly-owned subsidiary, Prosidion Limited, in Oxford, UK

Contact Details: Watlington Road Oxford Oxfordshire OX4 6LT United Kingdom Tel: 44 (0)1865 782600 Fax: 44 (0)1865 782601 Email: Info@Prosidion.com WWW: www.prosidion.com/

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Recent Publications by Prosidion Ltd:
5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats. The noradrenaline (NA) and serotonin reuptake inhibitor, sibutramine,...	6th June, 2009	Prosidion Research,	Obesity (Silver Spring). 2009 Mar;17(3):467-73. Epub 2008 Dec 11. DOI Direct Link
SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1. Allosteric activators of the glucose-sensing enzyme glucokinase (GK) are...	30th August, 2008	OSI) Prosidion, Windrush Court, Watlington Road, Oxford OX4 6LT, United	J Med Chem. 2008 Jul 24;51(14):4340-5. Epub 2008 Jun 28. DOI Direct Link
GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. GPR119 is a G protein-coupled receptor expressed predominantly in the...	29th April, 2008	(OSI) Prosidion,	Br J Pharmacol. 2008 Mar;153 Suppl 1:S76-81. Epub 2007 Nov 26. DOI Direct Link
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. BACKGROUND AND PURPOSE: Rimonabant (Acomplia, SR141716A), a cannabinoid...	26th February, 2008	Prosidion Limited, Windrush Court, Oxford, UK.	Br J Pharmacol. 2007 Nov;152(5):805-14. Epub 2007 Jun 25. DOI Direct Link
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions. AIMS/HYPOTHESIS: We evaluated the insulinotropic and antihyperglycaemic...	18th October, 2007	(OSI)Prosidion, Windrush Court, Watlington Road, Oxford, UK.	Diabetologia. 2007 Jun;50(6):1277-87. Epub 2007 Apr 6. DOI Direct Link
→View more Prosidion Ltd research publications.

Press Releases on Prosidion Ltd:
Life Sciences Day of DVC Deutsche Venture Capital – Highlights and	1st July, 2004	Dvc	Life Sciences Day of DVC Deutsche Venture Capital – Highlights and Trends in the Biotechno­logy-Sector in Germany 16. July 2004 III. Munich – The third Life Science Day of the DVC has taken
DVC Deutsche Venture Capital achieves a substantial return on the asset	1st January, 1970	Dvc	DVC Deutsche Venture Capital achieves a substantial return on the asset sale of portfolio company Probiodrug to Prosidion Ltd. 9th July 2004 Munich – DVC Deutsche Venture Capital, one of Europe

Prosidion Ltd Patents:
US Patent No.	Title
7582632	Tri(cyclo) substituted amide compounds
7262196	Tri(cyclo) substituted amide glucokinase activator compounds
7214681	Tri(cyclo) substituted amide compounds
7166579	Prodrugs of DP IV-inhibitors
7083933	Methods for identification of modulators of OSGPR116 activity
→View more Prosidion Ltd patents.

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