Recent Publications by Prosidion Ltd: |
5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats.
The noradrenaline (NA) and serotonin reuptake inhibitor, sibutramine,... | 6th June, 2009
| Prosidion Research,
| Obesity (Silver Spring). 2009 Mar;17(3):467-73. Epub 2008 Dec 11.
DOI Direct Link |
SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.
Allosteric activators of the glucose-sensing enzyme glucokinase (GK) are... | 30th August, 2008
| OSI) Prosidion, Windrush Court, Watlington Road, Oxford OX4 6LT, United
| J Med Chem. 2008 Jul 24;51(14):4340-5. Epub 2008 Jun 28.
DOI Direct Link |
GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity.
GPR119 is a G protein-coupled receptor expressed predominantly in the... | 29th April, 2008
| (OSI) Prosidion,
| Br J Pharmacol. 2008 Mar;153 Suppl 1:S76-81. Epub 2007 Nov 26.
DOI Direct Link |
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
BACKGROUND AND PURPOSE: Rimonabant (Acomplia, SR141716A), a cannabinoid... | 26th February, 2008
| Prosidion Limited, Windrush Court, Oxford, UK.
| Br J Pharmacol. 2007 Nov;152(5):805-14. Epub 2007 Jun 25.
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Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.
AIMS/HYPOTHESIS: We evaluated the insulinotropic and antihyperglycaemic... | 18th October, 2007
| (OSI)Prosidion, Windrush Court, Watlington Road, Oxford, UK.
| Diabetologia. 2007 Jun;50(6):1277-87. Epub 2007 Apr 6.
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Applying science to drug discovery.
Scientists and science in the pharmaceutical industry rely heavily on the... | 17th June, 2006
| Prosidion Ltd, Watlington Road, Oxford OX4 6LT, UK.
| Biochem Soc Trans. 2006 Apr;34(Pt 2):238-42.
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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.
The endogenous lipid signaling agent oleoylethanolamide (OEA) has recently... | 2nd May, 2006
| (OSI)Prosidion, Windrush Court, Watlington Road, Oxford OX4 6LT, UK.
| Cell Metab. 2006 Mar;3(3):167-75.
DOI Direct Link |
