Human Protein Atlas (HPA)

The protein atlas contains histological images from sections of human tissue. These images are equivalent to what is seen in a microscope when examining sections of tissue on glass slides. Each antibody in the database has been used for immunohistochemical staining of both normal and cancer tissue. The immunohistochemical protocols used result in a brown-black staining, localized where an antibody has bound to its corresponding antigen. The tissue section is furthermore histochemically stained with hematoxylin to enable visualization of microscopical features. Hematoxylin staining is unspecific and results in a blue coloring of both cells and extracellular material.Tissue microarrays have been used to enable immunohistochemical staining of a large number and variety of normal and cancerous tissues. The design of used tissue microarrays include samples of 48 different normal tissue types and 20 different types of cancer. For each antibody, protein expression patterns in normal tissue can be viewed as triplicates from 144 different individuals and in cancer tissue viewed as duplicates from 216 different patients. Normally, a fraction of the 576 images are missing for each antibody due to technical issues. Samples of normal and cancer tissue have been collected from anonymized paraffin embedded material of surgical specimens, in accordance with approval from the local ethics committee

Contact Details: Stockholm Uppsala Sweden Tel: Fax: Email: contact@hpr.se WWW: www.proteinatlas.org/

Press Releases on Human Protein Atlas (HPA):
Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM)	23rd June, 2009	Sigma-Aldrich	Additions to the Human Protein Atlas, available exclusively through Sigma-Aldrich, bring the portfolio to over 6,100 antibodies powered by Atlas Antibodies ST. LOUIS, June 23 /PRNewswire-FirstCall

BioNews Results for Human Protein Atlas (HPA):
Human Protein Atlas adopts Origene's Over-expression Lysates	GenomeWeb:  Nov 11 2009 5:41PM Matching: human protein atlas hpa

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