Protein Structure Factory

The term "Protein Structure Factory" stands for a common initiative of structural biologists from the Berlin area and the German Human Genome Project (DHGP). The Protein Structure Factory represents an integrative approach to the high-throughput analysis of three-dimensional protein structures.We have set out to establish an analytical infrastructure to characterize human proteins whose cDNA sequences are available at the Resource Center of the DHGP in Berlin. Target proteins are selected on grounds of predicted novelty of the structure as well as medical or biological relevance. We combine sequence analysis with bioinformatics, automated gene expression and protein purification, determination of a biophysical fingerprint and finally the three-dimensional protein structure analysis by either NMR spectroscopy or X-ray diffraction techniques. The crystal structure analysis will use the synchrotron radiation of the storage ring BESSY in Berlin

Contact Details: Robert-Roessle-Str. 10 Berlin D-13092 Germany Tel: 49 (0)30 9406 2987 Fax: 49 (0)30 9406 2925 Email: psf@fu-berlin.de WWW: www.proteinstrukturfabrik.de/

Recent Publications by Protein Structure Factory:
High throughput cloning with restriction enzymes. The systematic structural analysis of many target proteins involves...	19th August, 2008	Max Planck Institute for Molecular Genetics, Department of Vertebrate	Methods Mol Biol. 2008;426:163-73. DOI Direct Link
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. The human protein PTD012 is the longer product of an alternatively spliced...	19th August, 2006	Protein Structure Factory, Berlin 12489, Germany.	Protein Sci. 2006 Apr;15(4):914-20. Epub 2006 Mar 7. DOI Direct Link
X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1). BACKGROUND: Human Aortic Preferentially Expressed Protein-1 (APEG-1) is a...	13th June, 2006	Protein Structure Factory, c/o BESSY GmbH, Albert-Einstein-Str. 15, 12489	BMC Struct Biol. 2005 Dec 14;5:21. DOI Direct Link
A catalog of human cDNA expression clones and its application to structural genomics. We describe here a systematic approach to the identification of human...	21st May, 2005	Protein Structure Factory, Heubnerweg 6, 14059 Berlin, Germany.	Genome Biol. 2004;5(9):R71. Epub 2004 Aug 17. DOI Direct Link
X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880. The human protein FLJ36880 belongs to the fumarylacetoacetate hydrolase...	19th March, 2005	Protein Structure Factory, c/o BESSY GmbH, Albert-Einstein-Str. 15,	Biol Chem. 2004 Oct;385(10):935-42. DOI Direct Link
→View more Protein Structure Factory research publications.

BioNews Results for Protein Structure Factory:
Yale University: Yale's Thomas Steitz Shares 2009 Nobel Prize in Chemistry - Described Structure and Function of Life's Protein-Making Factory	Individual.com:  Oct 7 2009 5:19PM Matching: protein structure factory

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