CombiChem Incorporated

CombiChem is a computational product discovery company that is applying its proprietary design technology and rapid synthesis capabilities to accelerate the discovery process for new drugs and chemical products. CombiChem believe their approach offers pharmaceutical and chemical companies the opportunity to conduct their discovery efforts in a more productive and cost-effective manner. Using CombiChem's proprietary Discovery Engine(TM) process, they focus on the generation, evolution and optimization of potential new lead candidates for their collaborative partners who will then develop, manufacture, market and sell any resulting products. CombiChem believe that their process is widely applicable to a variety of disease targets and therapeutic indications as well as to other industries such as agrochemical, industrial chemical and materials science. CombiChem have established collaborative agreements with Athena Neurosciences, Inc., a wholly owned subsidiary of Elan Corporation, plc, ICOS Corporation, ImClone Systems Incorporated, Novartis Crop Protection AG, Ono Pharmaceutical Co., Ltd., Roche Bioscience, a division of Syntex (U.S.A.) Inc., Sumitomo Pharmaceuticals Co., Ltd. and Teijin Limited. In addition, CombiChem are using their approach on internal programs to discover new lead candidates that will then be outlicensed to third parties, while retaining a larger economic interest. In December 1998, CombiChem further broadened the application of their technology by establishing a joint venture with Chirotech Technology, Ltd., a member of the Chiroscience Group of companies, to commercialize libraries of chiral compounds. The joint venture, ChiroChem Discovery Services, LLC, was established to develop and sell specifically designed chiral compound libraries.

Contact Details: 9050 Camino Santa Fe San Diego CA 92121 United States of America Tel: 619 530 0484 Fax: 619 530 9998 Email:

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Recent Publications by CombiChem Incorporated:
Presence of a functional nitrate assimilation pathway in Mycobacterium smegmatis. Ability of Mycobacterium smegmatis to assimilate nitrate was evaluated in...	19th November, 2008	Combichem Bio Resource Center, National Chemical Laboratory, Dr. Homi	Microb Pathog. 2008 Jan;44(1):71-7. Epub 2007 Aug 14. DOI Direct Link
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors. A novel class of PARP-1 inhibitors was identified containing a...	15th October, 2008	Deltagen Research Laboratories (Former CombiChem, Inc.), 4570 Executive	Bioorg Med Chem Lett. 2008 Sep 15;18(18):5126-9. Epub 2008 Jul 27. DOI Direct Link
A simple whole cell based high throughput screening protocol using Mycobacterium bovis BCG for inhibitors against dormant and active tubercle bacilli. This study aimed at developing a whole cell based high throughput...	25th June, 2008	CombiChem Bio Resource Center, National Chemical Laboratory, Dr. Homi	J Microbiol Methods. 2008 Apr;73(1):62-8. Epub 2008 Feb 11. DOI Direct Link
Development of a simple assay protocol for high-throughput screening of Mycobacterium tuberculosis glutamine synthetase for the identification of novel inhibitors. Mycobacterium tuberculosis glutamine synthetase (GS) is an essential...	19th June, 2008	Combichem Bioresource Center, National Chemical Laboratory, Dr. Homi	J Biomol Screen. 2005 Oct;10(7):725-9. Epub 2005 Aug 29. DOI Direct Link
Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. SAR studies were conducted around lead compound 1 using high-throughput...	10th June, 2008	Deltagen Research Laboratories (Former CombiChem, Inc.), 4570 Executive	Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73. Epub 2008 Feb 10. DOI Direct Link
→View more CombiChem Incorporated research publications.

CombiChem Incorporated Patents:
US Patent No.	Title
6686353	Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
6210571	Automated on-line evaporating light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
6194612	Template for solution phase synthesis of combination libraries
6107313	Dopamine receptor antagonists
6077438	Automated on-line evaporation light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
→View more CombiChem Incorporated patents.

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