Recent Publications by Takeda San Diego: |
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV.
Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important... | 4th February, 2009
| Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121, USA.
| Curr Top Med Chem. 2008;8(17):1545-52.
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Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.
The aim of the present research was to characterize the pharmacokinetic,... | 25th October, 2008
| Takeda San Diego Inc, San Diego, CA 92121, USA.
| Eur J Pharmacol. 2008 Jul 28;589(1-3):306-14. Epub 2008 Apr 26.
DOI Direct Link |
Parallel SFC/MS-MUX screening to assess enantiomeric purity.
Enantiomeric excess (ee) was evaluated for two internally synthesized... | 11th October, 2008
| Department of Analytical Chemistry and Technology, Takeda San Diego, Inc.,
| Chirality. 2008 Aug;20(8):885-95.
DOI Direct Link |
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects.
BACKGROUND: Alogliptin is a highly selective dipeptidyl peptidase-4... | 2nd October, 2008
| Takeda San Diego, Inc., San Diego, California 92121, USA.
| Clin Ther. 2008 Mar;30(3):513-27.
DOI Direct Link |
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4... | 9th July, 2008
| Takeda San Diego, Drug Discovery, 10410 Science Center Drive, San Diego,
| Bioorg Med Chem Lett. 2008 Apr 1;18(7):2362-7. Epub 2008 Mar 4.
DOI Direct Link |
Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation.
An automated parallel four-column supercritical fluid chromatography... | 12th December, 2007
| Takeda San Diego, Inc., 10410 Science Center Drive, San Diego, CA 92121,
| J Chromatogr A. 2007 Oct 26;1169(1-2):193-204. Epub 2007 Sep 8.
DOI Direct Link |
Selection of molecules based on shape and electrostatic similarity: proof of concept of "electroforms".
Molecular shape and electrostatic distribution play a crucial role in... | 7th November, 2007
| Takeda San Diego, 10410 Science Center Drive, San Diego, California 92121,
| J Chem Inf Model. 2007 Sep-Oct;47(5):1829-38. Epub 2007 Sep 8.
DOI Direct Link |
Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase inhibitors using liquid chromatography/tandem mass spectrometry detection.
Cortisol is an important glucocorticoid that regulates many physiological... | 19th August, 2007
| Takeda San Diego, Inc., 10410 Science Center Dr., San Diego, CA 92121,
| Rapid Commun Mass Spectrom. 2006;20(11):1643-7.
DOI Direct Link |
Phosphopeptides enrichment using on-line two-dimensional strong cation exchange followed by reversed-phase liquid chromatography/mass spectrometry.
We have developed a method to isolate and enhance the detection of... | 9th September, 2006
| Takeda San Diego, Inc.,
| Anal Biochem. 2006 Jul 15;354(2):213-9. Epub 2006 May 11.
DOI Direct Link |
Characterization of the two catalytic domains in histone deacetylase 6.
Histone deacetylase 6 (HDAC6) is the only known HDAC with two potentially... | 7th April, 2006
| Takeda San Diego Inc., CA 92121, USA.
| Biochem Biophys Res Commun. 2006 Mar 3;341(1):45-50. Epub 2006 Jan 6.
DOI Direct Link |
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
Fibroblast activation protein alpha (FAPalpha) is highly expressed in... | 9th July, 2005
| Takeda San Diego,
| J Biol Chem. 2005 May 20;280(20):19441-4. Epub 2005 Apr 4.
DOI Direct Link |
