Synapse BV

Synapse BV is a working group within the Cardiovascular Research Institute Maastricht (CARIM) as well as a company within the Maastricht University Holding. It carries out developmental research in the field of the (patho-)physiology of haemostasis and thrombosis, operating in the niche between biochemistry and molecular biology on the one side and pharmaceutical- and clinical sciences on the other. It more specifically explores the overall function of the thrombin generating system in platelet poor- and platelet rich plasma and blood as a diagnostic tool and a pharmaceutical target. It cooperates with major pharmaceutical and diagnostic companies on such subjects as the mechanism of action of antiplatelet drugs and clotting factor inhibitors, the measurement of their effects in vitro and in vivo in animals and humans, as well as the development of diagnostic procedures based on the assessment of the overall function of the coagulation mechanism.

Contact Details: University MaastrichtP.O. Box 616 Maastricht 6200 MD Netherlands Tel: 31-43 3881675 Fax: 31-43 3884159 Email: info@thrombin.com WWW: www.thrombin.com/

Recent Publications by Synapse BV:
The technique of measuring thrombin generation with fluorescent substrates: 4. The H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration. In fluorogenic thrombin generation (TG) experiments, thrombin...	28th February, 2009	Synapse BV, Cardiovascular Research Institute CARIM, P. O. Box 616, 6200	Thromb Haemost. 2009 Jan;101(1):171-7.
The technique of measuring thrombin generation with fluorogenic substrates: 3. The effects of sample dilution. Assessing the clotting function inevitably brings about dilution of...	28th February, 2009	Synapse BV, Cardiovascular Research Institute CARIM, PO. Box 616, 6200 MD,	Thromb Haemost. 2009 Jan;101(1):165-70.
The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration. In fluorogenic thrombin generation (TG) measurement the concentrations of...	9th October, 2008	Synapse BV, Cardiovascular Research Institute CARIM, Maastricht, The	Thromb Haemost. 2008 Aug;100(2):343-9.
Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths. QUESTION: How does the size of the heparin moiety in the anti-thrombin...	16th September, 2008	Synapse BV, Cardiovascular Research Institute Maastricht (CARIM),	Thromb Res. 2008;122(2):237-45. Epub 2007 Nov 28. DOI Direct Link
Recollections on thrombin generation. Against an autobiographic background, a historical sketch is given of the...	2nd May, 2008	Synapse BV, Cardiovascular Research Institute Maastricht, University of	J Thromb Haemost. 2008 Feb;6(2):219-26. Epub 2007 Dec 10. DOI Direct Link
→View more Synapse BV research publications.

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