Xenome Ltd. was established to mine the diverse therapeutic potential of Australia's terrestrial and marine biota, to create a deep pipeline of potential solutions for unmet chronic conditions including severe intractable pain, inflammation and cancer. As the world's largest island continent, Australia's long period of geological isolation has resulted in the development of unique animals, plants and ecosystems. The diversity of this biota is reflected in the vast array of peptide toxins Australian venomous animals have evolved for prey capture and defense.
Venom peptides are highly prospective for drug discovery and development due to their inherent selectivity, potency and diverse mechanisms of action over a broad range of pharmacological targets. In addition they are readily amenable to rational and systemic optimization chemistry. Xenome has built a discovery portal and development pipeline based on rare access to this extraordinary chemical diversity, its expert skill set and sophisticated facilities.
| Contact Details: |
| 12707 High Bluff Drive,Suite 246 |
| San Diego |
| California |
| 92130 |
| United States of America |
| Tel: | 760 633 0007 |
| Fax: | 858 350 4319 |
| Email: | discovery@xenome.com |
| WWW: | www.XENOME.COM/
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Recent Publications by Xenome Ltd: |  |
chi-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain ( perpendicular).
Norepinephrine (NE) amplifies the strength of descending pain inhibition,... | 29th October, 2009
| Xenome Ltd., 120 Meiers Road, Indooroopilly, Queensland, Australia 4068.
| J Med Chem. 2009 Oct 27.
DOI Direct Link |
High-throughput synthesis of conopeptides: a safety-catch linker approach enabling disulfide formation in 96-well format.
Conotoxins exhibit a high degree of selectivity and potency for a range of... | 27th September, 2007
| Xenome Ltd, 120 Meiers Road, Indooroopilly 4068, Australia.
| J Pept Sci. 2007 Feb;13(2):133-41.
DOI Direct Link |
Taxonomy of Australian Funnel-web spiders using rp-HPLC/ESI-MS profiling techniques.
The complex nature of venom from spider species offers a unique natural... | 30th June, 2006
| Xenome Ltd, P.O. Box 6295, St Lucia, Qld 4067, Australia.
| Toxicon. 2006 May;47(6):614-27. Epub 2006 Mar 22.
DOI Direct Link |
Australian funnel-web spider venom analyzed with on-line RP-HPLC techniques.
The complex nature of venom from spider species offers a unique natural... | 25th March, 2004
| Xenome Ltd., Indooroopilly, Queensland, Australia.
| Methods Mol Biol. 2004;251:307-22.
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