Recent Publications by Astellas Pharma Ltd: |
Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats.
Glucagon-like peptide-1 (GLP-1), an incretin hormone, is essential for the... | 13th June, 2009
| Drug Discovery Research, Astellas Pharma Inc., Osaka and Tsukuba, Japan.
| Pharmacol Res. 2009 Apr 7.
DOI Direct Link |
QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells.
Recently, we discovered that transient receptor potential ankyrin1 channel... | 10th June, 2009
| Pharmacology Laboratories, Drug Discovery Research, Astellas Pharma Inc,
| Mol Cell Biochem. 2009 Jun 9.
DOI Direct Link |
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
As an extension of research conducted on beta(3)-adrenergic receptor... | 3rd June, 2009
| Chemistry Research Laboratories, Astellas Pharma Inc., 21, Miyukigaoka,
| J Med Chem. 2009 May 14;52(9):3063-72.
DOI Direct Link |
Effects of physicochemical properties of salting-out layer components on drug release.
A "Salting-out Taste-masking System" generates a long lag time for... | 22nd May, 2009
| Drug Delivery, Pharmaceutical Research and Technology Labs, Astellas
| Int J Pharm. 2009 Jul 6;376(1-2):13-21. Epub 2009 Apr 11.
DOI Direct Link |
Identification of human metabolites of YM758, a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepatic excretion of these metabolites.
YM758 is a novel inhibitor of If channel ('funny' If current channel)... | 15th May, 2009
| Astellas Pharma Inc.
| Drug Metab Dispos. 2009 May 13.
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Effect of the immunosuppressant histone deacetylase inhibitor FR276457 in a canine renal transplant model.
The histone deacetylase (HDAC) inhibitor FR276457, a hydroxamic... | 5th May, 2009
| Department of Immunology, Pharmacology Research Labs, Astellas Pharma
| Transpl Immunol. 2009 May 3.
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Improvement of FR901379 production by mutant selection and medium optimization.
FR901379 (WF11899A) is a novel echinocandin type of lipopeptide antibiotic... | 28th April, 2009
| Fermentation and Biotechnology Laboratories, Astellas Pharma Inc., 156
| J Biosci Bioeng. 2009 May;107(5):530-4.
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Infarction involving the insula and risk of mortality after stroke.
BACKGROUND: Cerebral infarction involving the insula has been associated... | 25th April, 2009
| Astellas Pharma US, Deerfield, Ill., USA.
| Cerebrovasc Dis. 2009;27(6):564-71. Epub 2009 Apr 24.
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Collaborative work on evaluation of ovarian toxicity. 12) Effects of 2- or 4-week repeated dose studies and fertility study of indomethacin in female rats.
2-week and 4-week general toxicity studies of indomethacin, a nonselective... | 25th April, 2009
| Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma
| J Toxicol Sci. 2009;34 Suppl 1:SP129-36.
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[Consideration on molecular imaging technology as a tool for drug research and development]
Molecular imaging technology such as positron emission tomography (PET)... | 22nd April, 2009
| Bioimaging, Applied Pharmacology Research Laboratories, Astellas Pharma
| Yakugaku Zasshi. 2009 Mar;129(3):297-304.
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Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.
In the search for potent and selective human beta3-adrenergic receptor... | 14th April, 2009
| Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan.
| Bioorg Med Chem. 2009 May 1;17(9):3283-94. Epub 2009 Mar 27.
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Synthesis and structure-activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists.
A series of... | 27th March, 2009
| Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka,
| Bioorg Med Chem. 2009 Apr 15;17(8):3130-41. Epub 2009 Mar 9.
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Vascular calcification and secondary hyperparathyroidism of severe chronic kidney disease and its relation to serum phosphate and calcium levels.
Background and purpose: Various complications consequent on disordered... | 24th March, 2009
| Diabetic Complications Department, Pharmacology Research Lab., Drug
| Br J Pharmacol. 2009 Mar 19.
DOI Direct Link |
