Recent Publications by Astellas Pharma Ltd: |
Disruption of the Ether-a-go-go K+ Channel Gene BEC1/KCNH3 Enhances Cognitive Function.
The K(+) channel, one of the determinants for neuronal excitability, is... | 20th November, 2009
| Drug Discovery Research, Astellas Pharma Inc., Ibaraki 305-8585, Japan,
| J Neurosci. 2009 Nov 18;29(46):14637-14645.
DOI Direct Link |
Response to the "Letter to the Editor of Pain" by Dr. Munro.
The K(+) channel, one of the determinants for neuronal excitability, is... | 19th November, 2009
| Pharmacology Research Labs., Drug Discovery Research, Astellas Pharma
| Pain. 2009 Nov 16.
DOI Direct Link |
A Comparison of Pharmacokinetics Between Humans and Monkeys.
To verify the availability of pharmacokinetic parameters in cynomolgus... | 17th November, 2009
| Astellas pharma Inc.
| Drug Metab Dispos. 2009 Nov 12.
DOI Direct Link |
Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors.
(2S,4S)-4-Fluoro-1-({[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino}acet... | 12th November, 2009
| Drug Discovery Research, Astellas Pharma Inc., 5-2-3, Toukoudai, Tuskuba,
| Pharmacol Rep. 2009 Sep-Oct;61(5):899-908.
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Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes.
A series of... | 11th November, 2009
| Drug Discovery Research, Astellas Pharma Inc, Tsukuba-shi, Ibaraki
| Bioorg Med Chem. 2009 Dec 15;17(24):8161-7. Epub 2009 Oct 23.
DOI Direct Link |
Time-dependent Inhibitory Effects of FK1706, a Novel Non-immunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in Vitro.
We investigated the inhibitory effects of FK1706, a novel... | 6th November, 2009
| 1 Astellas Pharma, Inc.;
| Drug Metab Dispos. 2009 Nov 4.
DOI Direct Link |
Behavioral and Urological Evaluation of a Testicular Pain Model.
OBJECTIVES: To develop an animal model of testicular pain to examine the... | 30th October, 2009
| Pharmacology Research Labs, Astellas Pharma Inc, Ibaraki, Japan.
| Urology. 2009 Oct 26.
DOI Direct Link |
Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.
Inosine 5'-monophosphate dehydrogenase (IMPDH) inhibition is a critical... | 21st October, 2009
| Pharmacology Research Laboratories, Astellas Pharma Inc., 21, Miyukigaoka,
| Int Immunopharmacol. 2009 Oct 18.
DOI Direct Link |
Characterization of human organic cation transporter 1 (OCT1/SLC22A1)-, and OCT2 (SLC22A2)-mediated transport of YM155 monobromide, a novel survivin suppressant.
YM155 monobromide,... | 17th October, 2009
| 1 Astellas Pharma, Inc.;
| Drug Metab Dispos. 2009 Oct 15.
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Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
BACKGROUND: Valproic acid (VPA) is used to treat epilepsy and bipolar... | 16th October, 2009
| Drug Safety Research Laboratories, Astellas Pharma Inc., Yodogawa-ku,
| Birth Defects Res B Dev Reprod Toxicol. 2009 Oct;86(5):394-401.
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Healthcare costs of GERD and acid-related conditions in pediatric patients, with comparison between histamine-2 receptor antagonists and proton pump inhibitors.
BACKGROUND: Gastroesophageal reflux disease and acid-related conditions... | 25th September, 2009
| Astellas Pharma US, Inc., Deerfield, IL, USA.
| Curr Med Res Opin. 2009 Nov;25(11):2703-9.
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Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.
Sulfonylureas promote insulin secretion and potently lower blood glucose... | 22nd September, 2009
| Applied Pharmacology Research Labs, Drug Discovery Research, Astellas
| Eur J Pharmacol. 2009 Nov 10;622(1-3):71-7. Epub 2009 Sep 17.
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Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Although it is known that both clonidine and loperamide cause delayed... | 16th September, 2009
| Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan.
| Pharmacology. 2009;84(4):227-33. Epub 2009 Sep 10.
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Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.
Signal transducers and activators of transcription 6 (STAT6) is an... | 15th September, 2009
| Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba,
| Bioorg Med Chem. 2009 Oct 1;17(19):6926-36. Epub 2009 Aug 15.
DOI Direct Link |
