Recent Publications by Astellas Pharma Ltd: |
Behavioral and Urological Evaluation of a Testicular Pain Model.
OBJECTIVES: To develop an animal model of testicular pain to examine the... | 30th October, 2009
| Pharmacology Research Labs, Astellas Pharma Inc, Ibaraki, Japan.
| Urology. 2009 Oct 26.
DOI Direct Link |
Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.
Inosine 5'-monophosphate dehydrogenase (IMPDH) inhibition is a critical... | 21st October, 2009
| Pharmacology Research Laboratories, Astellas Pharma Inc., 21, Miyukigaoka,
| Int Immunopharmacol. 2009 Oct 17.
DOI Direct Link |
Characterization of human organic cation transporter 1 (OCT1/SLC22A1)-, and OCT2 (SLC22A2)-mediated transport of YM155 monobromide, a novel survivin suppressant.
YM155 monobromide,... | 17th October, 2009
| 1 Astellas Pharma, Inc.;
| Drug Metab Dispos. 2009 Oct 15.
DOI Direct Link |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
BACKGROUND: Valproic acid (VPA) is used to treat epilepsy and bipolar... | 16th October, 2009
| Drug Safety Research Laboratories, Astellas Pharma Inc., Osaka, Japan.
| Birth Defects Res B Dev Reprod Toxicol. 2009 Oct 14;86(5):394-401.
DOI Direct Link |
Healthcare costs of GERD and acid-related conditions in pediatric patients, with comparison between histamine-2 receptor antagonists and proton pump inhibitors.
BACKGROUND: Gastroesophageal reflux disease and acid-related conditions... | 25th September, 2009
| Astellas Pharma US, Inc., Deerfield, IL, USA.
| Curr Med Res Opin. 2009 Nov;25(11):2703-9.
DOI Direct Link |
Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.
Sulfonylureas promote insulin secretion and potently lower blood glucose... | 22nd September, 2009
| Applied Pharmacology Research Labs, Drug Discovery Research, Astellas
| Eur J Pharmacol. 2009 Nov 10;622(1-3):71-7. Epub 2009 Sep 17.
DOI Direct Link |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Although it is known that both clonidine and loperamide cause delayed... | 16th September, 2009
| Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan.
| Pharmacology. 2009;84(4):227-33. Epub 2009 Sep 10.
DOI Direct Link |
Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.
Signal transducers and activators of transcription 6 (STAT6) is an... | 15th September, 2009
| Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba,
| Bioorg Med Chem. 2009 Oct 1;17(19):6926-36. Epub 2009 Aug 15.
DOI Direct Link |
Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
BACKGROUND AND PURPOSE: The lipid phosphatase known as SH2... | 22nd August, 2009
| Astellas Pharma Inc., Miyukigaoka, Tsukuba-shi, Ibaraki, Japan.
| Br J Pharmacol. 2009 Oct;158(3):879-87. Epub 2009 Aug 19.
DOI Direct Link |
Characterization of a 2,4-dinitrochlorobenzene-induced chronic dermatitis model in rats.
Although many mouse models of atopic dermatitis have been reported, few... | 20th August, 2009
| Applied Pharmacology Research Laboratories, Drug Discovery Research,
| Skin Pharmacol Physiol. 2009;22(5):240-7. Epub 2009 Aug 18.
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Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Although epidemiological studies have shown that long-term treatment with... | 12th August, 2009
| Department of Neuroscience, Pharmacology Research Labs, Astellas Pharma
| Brain Res. 2009 Oct 27;1295:186-91. Epub 2009 Aug 8.
DOI Direct Link |
Simultaneous quantitative analysis of N-acylethanolamides in clinical samples.
A simple and rapid analytical method is described for the simultaneous... | 12th August, 2009
| Exploratory Development Department, Astellas Pharma Global Development
| Anal Biochem. 2009 Dec 1;395(1):68-76. Epub 2009 Aug 8.
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A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
A rapid and selective liquid chromatography/tandem mass spectrometric... | 4th August, 2009
| Astellas Pharma Europe B.V., Exploratory Development Department,
| Biomed Chromatogr. 2009 Aug 2.
DOI Direct Link |
Effects of Tamsulosin on Bladder Blood Flow and Bladder Function in Rats With Bladder Outlet Obstruction.
OBJECTIVES: To investigate the mechanism underlying the ameliorating... | 4th August, 2009
| Applied Pharmacology Research Laboratories, Astellas Pharma Inc,
| Urology. 2009 Jul 30.
DOI Direct Link |
