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GTXGTx, Inc., headquartered in Memphis, Tennessee, is a biopharmaceutical company dedicated to the discovery, development and commercialization of novel hormonal therapeutics for cancer and serious conditions related to men’s health. GTx's lead drug discovery and development programs are focused on small molecules that selectively modulate the effects of estrogens and androgens.
GTx is developing ACAPODENE® (toremifene citrate), a selective estrogen receptor modulator, or SERM, in two separate clinical programs in men: first, a pivotal Phase III clinical trial evaluating ACAPODENE® 80 mg for the treatment of serious side effects of androgen deprivation therapy for advanced prostate cancer, and second, a pivotal Phase III clinical trial evaluating ACAPODENE® 20 mg for the prevention of prostate cancer in high risk men with the premalignant lesion known as high grade prostatic intraepithelial neoplasia. GTx has licensed to Ipsen Group exclusive rights in Europe to develop and commercialize ACAPODENE®.
GTx also is developing ostarine, a first-in-class selective androgen receptor modulator, or SARM. GTx believes that ostarine has the potential to treat a variety of indications, including cancer cachexia, end stage renal disease muscle wasting, frailty and osteoporosis. GTx plans to initiate a Phase IIb ostarine clinical trial for cancer cachexia by the summer of 2007.
GTx also has an extensive preclinical pipeline generated from a world-class discovery program which includes the specific product candidates prostarine, a SARM for benign prostatic hyperplasia, and andromustine, an anticancer product candidate, for hormone refractory prostate cancer.
| Contact Details: |
| 3 North Dunlap Street |
| Memphis |
| Tennessee |
| 38163 |
| United States of America |
| Tel: | 901.523.9700 Ext.170 |
| Fax: | 901.523.9772 |
| Email: | investor.relations@gtxinc.com |
| WWW: | www.gtxinc.com/
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Recent Publications by GTX: |  |
Recent and emerging anti-diabetes targets.
Diabetes is a disease that affects over 150 million people worldwide for... | 3rd September, 2009
| Preclinical Research and Development, GTx, Inc., 3 N. Dunlap Street,
| Med Res Rev. 2009 Jan;29(1):125-95.
DOI Direct Link |
Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
Lithium/silver vanadium oxide (SVO) batteries have been under development... | 15th July, 2009
| Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street,
| J Med Chem. 2009 Jun 25;52(12):3597-617.
DOI Direct Link |
Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.
Androgen receptor (AR) ligands are important for the development and... | 12th June, 2009
| Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street,
| Mol Endocrinol. 2008 Nov;22(11):2448-65. Epub 2008 Sep 18.
DOI Direct Link |
[The clinical detection of breast cancer by spectrum method]
Breast cancer is one of the most frequently encountered malignant tumors... | 11th March, 2009
| Department of Biomedical Engineering, Tsinghua University, Beijing 100084,
| Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Nov;28(11):2531-5.
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Selective androgen receptor modulators in preclinical and clinical development.
Androgen receptor (AR) plays a critical role in the function of several... | 3rd February, 2009
| Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA.
| Nucl Recept Signal. 2008;6:e010. Epub 2008 Nov 26.
DOI Direct Link |
→View more GTX research publications. |
Press Releases on GTX:
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| Reportlinker Adds Power Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 |
20th November, 2009 |
Reportlinker |
NEW YORK, Nov. 20 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.
Power Wheelchair Market Shares, Strategies, and Forecasts, Worldwide,
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| Reportlinker Adds Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 |
3rd November, 2009 |
Reportlinker |
NEW YORK, Nov. 3 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.
Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to
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