Orthologic

OrthoLogic is a biotechnology company committed to developing a pipeline of novel peptides and other molecules aimed at helping patients with under-served conditions. The Company is focused on the development and commercialization of two product platforms: Chrysalin® (TP508) and AZX100. Chrysalin, the Company’s novel synthetic peptide, is being studied in two lead indications, both of which represent areas of significant unmet medical need – fracture repair and diabetic foot ulcer healing. Based on the Company’s pioneering scientific research of the natural healing cascade, OrthoLogic has become a leading company focused on tissue and bone repair. The Company owns exclusive worldwide rights to Chrysalin. AZX100 is a novel pre-clinical 24-amino acid peptide, the first of a new class of compounds in the field of smooth muscle relaxation called Intracellular Actin Relaxing Molecules, or ICARMs™. AZX100 is currently being evaluated for medically and commercially significant applications, such as the treatment of vasospasm associated with subarachnoid hemorrhage, the prevention of keloid scarring and the treatment of asthma. OrthoLogic has an exclusive worldwide license to AZX100.

Contact Details: 1275 West Washington Tempe AZ 85281 United States of America Tel: 800.937.5520 or 602.286.5520 Fax: Email: investorinquiries@olgc.com WWW: www.orthologic.com/

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Recent Publications by Orthologic:
Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues. The thrombin peptide, TP508, also known as Chrysalin (OrthoLogic, Tempe,...	24th March, 2007	OrthoLogic Corp, 1275 West Washington Street, Tempe, AZ 85281, USA.	J Bone Joint Surg Am. 2006 Nov;88 Suppl 3:132-9. DOI Direct Link
Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis. Previous studies have shown that a single injection of thrombin peptide...	16th June, 2005	Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA.	J Orthop Res. 2005 May;23(3):671-9. Epub 2004 Dec 15. DOI Direct Link
Repair of rabbit segmental defects with the thrombin peptide, TP508. The synthetic peptide, TP508 (Chrysalin), was delivered to rabbit...	17th September, 2004	Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA.	J Orthop Res. 2004 Sep;22(5):1094-9. DOI Direct Link

BioNews Results for Orthologic:
Capstone Therapeutics to Host Conference Call Discussing Third Quarter 2009 Operating Results	Therapeutics Daily:  Nov 4 2009 2:58PM Matching: orthologic
Capstone Therapeutics to Host Conference Call Discussing Third Quarter 2009 Operating Results	Individual.com:  Nov 4 2009 3:14PM Matching: orthologic
Capstone Therapeutics to Present at 4th Annual BIOCOM Investor Conference	Therapeutics Daily:  Oct 23 2009 1:26AM Matching: orthologic

Orthologic Patents:
US Patent No.	Title
7456250	Thrombin peptide derivative dimers
5547459	Ultrasonic bone-therapy apparatus and method
5651363	Ultrasonic bone assessment method and apparatus
5738636	Continuous passive motion devices for joints
5752924	Ultrasonic bone-therapy apparatus and method
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