Recent Publications by Enzon Incorporated: |
Marked therapeutic efficacy of a novel polyethylene glycol-SN38 conjugate, EZN-2208, in xenograft models of B-cell non-Hodgkin's lymphoma.
Examination of the clinical utility of SN38... | 2nd October, 2009
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, NJ 08854,
| Haematologica. 2009 Oct;94(10):1456-9.
DOI Direct Link |
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth.
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a... | 23rd December, 2008
| Enzon Pharmaceuticals Inc., 20 Kingsbridge Road, Piscataway, NJ 08854,
| Mol Cancer Ther. 2008 Nov;7(11):3598-608. Epub 2008 Oct 30.
DOI Direct Link |
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.
Tumor necrosis factor alpha (TNFalpha) has been used to treat patients... | 17th December, 2008
| Department of Oncology, Wyeth Research, Pearl River, New York, USA.
| Cancer Res. 2008 Nov 15;68(22):9519-24.
DOI Direct Link |
Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers.
CPT-11, also known as irinotecan, is a prodrug that is approved for the... | 29th July, 2008
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2008 Apr;19(4):849-59. Epub 2008 Mar 28.
DOI Direct Link |
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.
PURPOSE: Clinical development of SN38, the active metabolite of... | 21st May, 2008
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey 08854, USA.
| Clin Cancer Res. 2008 Mar 15;14(6):1888-96.
DOI Direct Link |
Releasable PEGylation of proteins with customized linkers.
Releasable PEGylation employs customized linkers that reversibly tether a... | 6th May, 2008
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Adv Drug Deliv Rev. 2008 Jan 3;60(1):29-49. Epub 2007 Aug 16.
DOI Direct Link |
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed... | 30th August, 2007
| Enzon Pharmaceuticals, Incorporated, 20 Kingsbridge Road, Piscataway, New
| Bioconjug Chem. 2007 May-Jun;18(3):773-84. Epub 2007 Mar 9.
DOI Direct Link |
Antibody engineering and modification technologies.
Antibody engineering has become a well-developed discipline, encompassing... | 27th July, 2007
| Enzon Pharmaceuticals, Piscataway, NJ 08854-3969, USA.
| Biomol Eng. 2007 Jun;24(2):201-15. Epub 2007 Mar 31.
DOI Direct Link |
Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.
In order to overcome the problems of enzymatic degradation and short... | 11th July, 2007
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, NJ 08820, United
| J Control Release. 2007 Jun 4;119(2):143-52. Epub 2006 Dec 29.
DOI Direct Link |
Comparative immunotoxicity evaluation of amphotericin B and ABELCET, an amphotericin B lipid complex (ABLC).
ABELCET, an amphotericin B lipid complex formulation (ABLC) and an... | 8th February, 2007
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey 08854, USA.
| Int J Toxicol. 2006 Nov-Dec;25(6):487-92.
DOI Direct Link |
Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.
Antitumor effect of poly(ethylene glycol)-camptothecin conjugate (PEG-CPT)... | 20th January, 2007
| Enzon Pharmaceuticals, Inc., Piscataway, NJ 08854, USA.
| J Control Release. 2005 Dec 10;110(1):90-102. Epub 2005 Nov 4.
DOI Direct Link |
Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.
Arginine is an important metabolite in the normal function of several... | 16th January, 2007
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 Nov-Dec;17(6):1447-59.
DOI Direct Link |
Safety evaluation of ABELCET, an amphotericin B lipid complex (ABLC): toxicity studies in rats.
ABELCET (ABLC) is a widely used amphotericin B lipid complex formulation... | 19th August, 2006
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey, USA.
| Int J Toxicol. 2006 Jul-Aug;25(4):285-94.
DOI Direct Link |
Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the... | 25th July, 2006
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 May-Jun;17(3):618-30.
DOI Direct Link |
Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.
The utility of PEGylation for improving therapeutic protein pharmacology... | 13th July, 2006
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 Mar-Apr;17(2):341-51.
DOI Direct Link |
