Recent Publications by Enzon Incorporated: |
Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers.
CPT-11, also known as irinotecan, is a prodrug that is approved for the... | 29th July, 2008
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2008 Apr;19(4):849-59. Epub 2008 Mar 28.
DOI Direct Link |
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.
PURPOSE: Clinical development of SN38, the active metabolite of... | 21st May, 2008
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey 08854, USA.
| Clin Cancer Res. 2008 Mar 15;14(6):1888-96.
DOI Direct Link |
Releasable PEGylation of proteins with customized linkers.
Releasable PEGylation employs customized linkers that reversibly tether a... | 6th May, 2008
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Adv Drug Deliv Rev. 2008 Jan 3;60(1):29-49. Epub 2007 Aug 16.
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Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed... | 30th August, 2007
| Enzon Pharmaceuticals, Incorporated, 20 Kingsbridge Road, Piscataway, New
| Bioconjug Chem. 2007 May-Jun;18(3):773-84. Epub 2007 Mar 9.
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Antibody engineering and modification technologies.
Antibody engineering has become a well-developed discipline, encompassing... | 27th July, 2007
| Enzon Pharmaceuticals, Piscataway, NJ 08854-3969, USA.
| Biomol Eng. 2007 Jun;24(2):201-15. Epub 2007 Mar 31.
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Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.
In order to overcome the problems of enzymatic degradation and short... | 11th July, 2007
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, NJ 08820, United
| J Control Release. 2007 Jun 4;119(2):143-52. Epub 2006 Dec 29.
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Comparative immunotoxicity evaluation of amphotericin B and ABELCET, an amphotericin B lipid complex (ABLC).
ABELCET, an amphotericin B lipid complex formulation (ABLC) and an... | 8th February, 2007
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey 08854, USA.
| Int J Toxicol. 2006 Nov-Dec;25(6):487-92.
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Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.
Antitumor effect of poly(ethylene glycol)-camptothecin conjugate (PEG-CPT)... | 20th January, 2007
| Enzon Pharmaceuticals, Inc., Piscataway, NJ 08854, USA.
| J Control Release. 2005 Dec 10;110(1):90-102. Epub 2005 Nov 4.
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Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.
Arginine is an important metabolite in the normal function of several... | 16th January, 2007
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 Nov-Dec;17(6):1447-59.
DOI Direct Link |
Safety evaluation of ABELCET, an amphotericin B lipid complex (ABLC): toxicity studies in rats.
ABELCET (ABLC) is a widely used amphotericin B lipid complex formulation... | 19th August, 2006
| Enzon Pharmaceuticals, Inc., Piscataway, New Jersey, USA.
| Int J Toxicol. 2006 Jul-Aug;25(4):285-94.
DOI Direct Link |
Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the... | 25th July, 2006
| Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 May-Jun;17(3):618-30.
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Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.
The utility of PEGylation for improving therapeutic protein pharmacology... | 13th July, 2006
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2006 Mar-Apr;17(2):341-51.
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An unexpected amide bond cleavage: poly (ethylene glycol) transport forms of vancomycin. 2.
PEG-amide vancomycin derivatives (V(3) position) have been synthesized and... | 7th January, 2006
| Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, NJ 08854,
| Eur J Med Chem. 2005 Aug;40(8):798-804. Epub 2005 Apr 22.
DOI Direct Link |
A new platform for oligonucleotide delivery utilizing the PEG prodrug approach.
The oligonucleotide (oligo, ODN), Genasense (GS), an ODN currently waiting... | 13th December, 2005
| Enzon Pharmaceuticals Inc., 20 Kingsbridge Road, Piscataway, New Jersey
| Bioconjug Chem. 2005 Jul-Aug;16(4):758-66.
DOI Direct Link |
