Enzon Incorporated

Enzon Incorporated is a biopharmaceutical company that develops, manufactures and markets enhanced therapeutics for life-threatening diseases through the application of its two proprietary technologies: (i) polyethylene glycol ("PEG") Modification or the PEG Process and (ii) single-chain antigen-binding ("SCA(R)") proteins. Enzon is focusing its internalresearch activities on applying its proprietary technologies to compounds of known therapeutic efficacy in order to enhance the performance of these compounds. Enzon is commercializing its proprietary technologies by developing products internally and in cooperation with strategic partners. To date, Enzon and its partners have successfully commercialized two products, ONCASPAR(R) and ADAGEN(R).

Contact Details: 20 Kingsbridge Road Piscataway NJ 08854 United States of America Tel: 732 980 4500 Fax: 732 980 5911 Email: WWW: www.enzon.com/

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Recent Publications by Enzon Incorporated:
Marked therapeutic efficacy of a novel polyethylene glycol-SN38 conjugate, EZN-2208, in xenograft models of B-cell non-Hodgkin's lymphoma. Examination of the clinical utility of SN38...	2nd October, 2009	Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, NJ 08854,	Haematologica. 2009 Oct;94(10):1456-9. DOI Direct Link
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a...	23rd December, 2008	Enzon Pharmaceuticals Inc., 20 Kingsbridge Road, Piscataway, NJ 08854,	Mol Cancer Ther. 2008 Nov;7(11):3598-608. Epub 2008 Oct 30. DOI Direct Link
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. Tumor necrosis factor alpha (TNFalpha) has been used to treat patients...	17th December, 2008	Department of Oncology, Wyeth Research, Pearl River, New York, USA.	Cancer Res. 2008 Nov 15;68(22):9519-24. DOI Direct Link
Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers. CPT-11, also known as irinotecan, is a prodrug that is approved for the...	29th July, 2008	Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, New Jersey	Bioconjug Chem. 2008 Apr;19(4):849-59. Epub 2008 Mar 28. DOI Direct Link
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model. PURPOSE: Clinical development of SN38, the active metabolite of...	21st May, 2008	Enzon Pharmaceuticals, Inc., Piscataway, New Jersey 08854, USA.	Clin Cancer Res. 2008 Mar 15;14(6):1888-96. DOI Direct Link
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BioNews Results for Enzon Incorporated:
News and FDA Updates for Bioanalytical Systems (NASDAQ:BASI), Enzon (Nasdaq:ENZN)	Los Angeles Chronicle:  Nov 21 2009 4:44AM Matching: enzon
Enzon sells specialty pharmaceutical business	Njbiz:  Nov 21 2009 12:42AM Matching: enzon
Enzon Presents Data at 2009 EORTC Meeting	Pharmacy Choice:  Nov 19 2009 9:36PM Matching: enzon
Enzon Presents Data at 2009 EORTC Meeting	SmartBrief:  Nov 19 2009 6:31PM Matching: enzon
Enzon Presents Data at 2009 EORTC Meeting	Freshnews.com:  Nov 19 2009 8:50PM Matching: enzon
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Enzon Incorporated Clinical Trials:
Efficacy of Pegamotecan (PEG-Camptothecin) in Localized or Metastatic Cancer of the Stomach or Gastroesophageal Junction

Enzon Incorporated Patents:
US Patent No.	Title
6121424	Multivalent antigen-binding proteins
6515110	Multivalent antigen-binding proteins
6566506	Non-antigenic branched polymer conjugates
6608076	Camptothecin derivatives and polymeric conjugates thereof
6624142	Trimethyl lock based tetrapartate prodrugs
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