Recent Publications by 3-Dimensional Pharmaceuticals Incorporated: |
Docking: successes and challenges.
The state of the art of various computational aspects of docking-based... | 19th October, 2005
| 3-Dimensional Pharmaceuticals, Cedarbrook Corporate Center, 8 Clarke
| Curr Pharm Des. 2005;11(3):323-33.
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[Targeted anticancer drugs and their development]
The state of the art of various computational aspects of docking-based... | 11th May, 2005
| 3-Dimensional Pharmaceuticals, Johnson & Johnson Pharmaceutical Research
| Duodecim. 2004;120(19):2323-30.
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Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.
A convenient synthetic route to novel 4-arylpyrazoles is described. The... | 25th March, 2005
| 3-Dimensional Pharmaceuticals, Inc., A wholly owned Johnson & Johnson
| Bioorg Med Chem Lett. 2004 Oct 4;14(19):4949-53.
DOI Direct Link |
Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands.
Studies on integrin alphaVbeta3 have implicated this receptor in a number... | 11th February, 2005
| 3-Dimensional Pharmaceuticals, Inc, Eagleview Corporate Center, 665
| Bioorg Med Chem Lett. 2004 Sep 6;14(17):4553-5.
DOI Direct Link |
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
Through structure-based drug design and parallel synthesis, we have... | 8th February, 2005
| 3-Dimensional Pharmaceuticals, Inc., 665 Stockton Drive, Exton, PA 19341,
| Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31.
DOI Direct Link |
Development of a quantitative, high-throughput cell-based enzyme-linked immunosorbent assay for detection of colony-stimulating factor-1 receptor tyrosine kinase inhibitors.
Inhibitors of receptor tyrosine kinases are implicated as therapeutic... | 3rd February, 2005
| Department of Discovery Biology, 3-Dimensional Pharmaceuticals Inc., 665
| J Biochem Biophys Methods. 2004 Jul 30;60(1):69-79.
DOI Direct Link |
A novel series of potent and selective small molecule inhibitors of the complement component C1s.
Activation of the classical pathway of complement has been implicated in... | 7th January, 2005
| 3-Dimensional Pharmaceuticals Inc, 665 Stockton Drive, Exton, PA 19341,
| Bioorg Med Chem Lett. 2004 Jun 21;14(12):3043-7.
DOI Direct Link |
A method for quantifying and visualizing the diversity of QSAR models.
Feature selection is one of the most commonly used and reliable methods... | 22nd October, 2004
| 3-Dimensional Pharmaceuticals, Inc., 8 Clarke Drive, Cranbury, NJ 08512,
| J Mol Graph Model. 2004 Mar;22(4):275-84.
DOI Direct Link |
5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1 H-pyrazole-4-carbonitrile (CTOM): synthesis and characterization of a novel and selective insect GABA receptor radioligand.
Pyrazole 2a is a novel, potent ligand for insect GABA receptors obtained... | 9th July, 2004
| 3-Dimensional Pharmaceuticals, Inc., 665 Stockton Drive, Suite 104, Exton,
| Bioorg Med Chem Lett. 2003 Nov 17;13(22):4035-7.
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Using in vitro human tissues to predict pharmacokinetic properties.
Pressure on drug discovery teams to predict the success of drug candidates... | 15th June, 2004
| 3-Dimensional Pharmaceuticals Inc, 665 Stockton Drive, Exton, PA 19341,
| Curr Opin Drug Discov Devel. 2004 Jan;7(1):69-74.
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Solid-phase synthesis of a library of hydroxyproline derivatives.
The synthesis of a library of N-alkylated O-arylated hydroxyproline... | 4th June, 2004
| 3-Dimensional Pharmaceuticals, Inc., 8 Clarke Drive, Cranbury, New Jersey
| J Comb Chem. 2004 Jan-Feb;6(1):91-8.
DOI Direct Link |
Solid-Phase Synthesis of 2,4-diaminopyrimidines via Lewis acid-mediated aromatic nucleophilic substitution.
Primary amines were immobilized on... | 11th May, 2004
| 3-Dimensional Pharmaceuticals Inc., 8 Clarke Drive, Cranbury, New Jersey
| J Comb Chem. 2004 May-Jun;6(3):414-9.
DOI Direct Link |
