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Avalon PharmaceuticalsAvalon Pharmaceuticals' primary mission is to discover and develop innovative small molecule therapeutics using cutting-edge genomic technologies. Through its comprehensive genomics approach, Avalon is able to pinpoint proprietary drug activity markers and drug targets and to use these for drug screening in complex biological systems, facilitating the identification of lead drug candidates. Avalon is developing these drug candidates both internally and through partnerships within the pharmaceutical industry.
By attracting a leading team of innovative scientists and drug discovery experts, utilizing cutting-edge genomics tools, and forming strategic alliances within the industry, Avalon is significantly decreasing the time it takes to develop novel drug therapies to treat deseases. Within the Company's first two-years, Avalon scientists were able to use their novel genomic discovery and screening approaches to identify several small molecule drug candidates for the treatment of cancer.
Avalon identifies small molecule therapeutic compounds directly from genomics data in three steps:
Identification of novel and key proprietary drug activity markers using a comprehensive set of genomics tools including molecular and pathological characterization, cytogenetics, and high density gene expression arrays,
Screening for new small molecule therapeutic compounds using its proprietary methods such as the Company's multi-parameter assays, and
Optimization of lead compounds using cutting-edge medicinal chemistry.
The company's initial therapeutic focus area is solid tumors including cancers of colon, breast, lung, and prostate.
Avalon's strategy of combining the latest genomic approaches for gene and target identification with an aggressive pursuit of small molecule drug discovery has attracted significant interest from the pharmaceutical industry. In order to quickly pursue large-scale discovery and drug development within particular disease areas, Avalon enters partnerships with pharmaceutical companies as well as collaborative agreements with clinical and academic institutions.
| Contact Details: |
| 20358 Seneca Meadows Parkway |
| Germantown |
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| 20876 |
| United States of America |
| Tel: | 301-556-1000 |
| Fax: | 301-556-1100 |
| Email: | info@avalonrx.com |
| WWW: | www.avalonrx.com/
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Recent Publications by Avalon Pharmaceuticals: |  |
A phase I dose-ranging study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of AVN944, an IMPDH inhibitor, in healthy male volunteers.
A phase I study of AVN944, an inosine monophosphate dehydrogenase (IMPDH)... | 26th February, 2009
| Avalon Pharmaceuticals, 20358 Seneca Meadows Parkway, Germantown, MD
| J Clin Pharmacol. 2009 Jan;49(1):30-8. Epub 2008 Oct 29.
DOI Direct Link |
Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening platform.
With recent advances in robotics and high-content screening and analysis... | 28th April, 2006
| Avalon Pharmaceuticals, Inc., 20358 Seneca Meadows Parkway, Germantown, MD
| Pharmacogenomics. 2006 Mar;7(2):227-35.
DOI Direct Link |
Expression biomarkers for clinical efficacy and outcome prediction in cancer.
Progress in cancer treatment has been slow, and the outlook for curing... | 28th February, 2006
| Avalon Pharmaceuticals, Inc., 20358 Seneca Meadows Parkway, Germantown, MD
| Pharmacogenomics. 2006 Jan;7(1):105-15.
DOI Direct Link |
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